Nup88 Antibody (H-7): sc-365868
- Nup88 Antibody (H-7) is a mouse monoclonal IgG2b κ Nup88 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of Nup88 of human origin
- Nup88 Antibody (H-7) is recommended for detection of Nup88 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Nup88 Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Nup88 (H-7): sc-365868.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Nup88 Antibody (H-7) for WB and IHC(P) applications. These reagents are now offered in bundles with Nup88 Antibody (H-7) (see ordering information below).
Nup88 Antibody (H-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects Nup88 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Nup88 (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Nup88, a 741 amino acid nucleoporin, plays a critical role in the nuclear pore complex (NPC), which is essential for regulating the transport of macromolecules between the nucleus and cytoplasm in eukaryotic cells. The NPC is composed of over 100 different subunits, many of which are nucleoporins characterized by O-linked-N-acetylglucosamine modifications and a unique pentapeptide repeat (XFXFG). Nup88 is not only ubiquitously expressed but also undergoes phosphorylation by ATM or ATR, which is significant for its function in cellular signaling pathways. Nup88 has been found to be upregulated in various malignant neoplasms and precancerous dysplasias, indicating potential involvement in tumorigenesis. The gene encoding Nup88 is located on human chromosome 17, a region that encompasses more than 2.5% of the human genome and contains over 1,200 genes, highlighting the complexity and importance of this protein in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Nup88 Antibody (H-7) References:
- The nuclear pore complex: from molecular architecture to functional dynamics. | Stoffler, D., et al. 1999. Curr Opin Cell Biol. 11: 391-401. PMID: 10395558
- The nuclear pore complex protein Nup88 is overexpressed in tumor cells. | Martínez, N., et al. 1999. Cancer Res. 59: 5408-11. PMID: 10554006
- A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development. | Gould, VE., et al. 2000. Am J Pathol. 157: 1605-13. PMID: 11073820
- Nup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis. | Gould, VE., et al. 2002. Hum Pathol. 33: 536-44. PMID: 12094380
- Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer. | Agudo, D., et al. 2004. Int J Cancer. 109: 717-20. PMID: 14999780
- Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus. | Andres-Hernando, A., et al. 2008. J Biol Chem. 283: 25082-90. PMID: 18606815
- The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88. | Fornerod, M., et al. 1997. EMBO J. 16: 807-16. PMID: 9049309
- Chromosomal localization of genes encoding CAN/Nup214-interacting proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32. | Fornerod, M., et al. 1997. Genomics. 42: 538-40. PMID: 9205132
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nup88 Antibody (H-7) | sc-365868 | 200 µg/ml | $316.00 | |||
Nup88 Antibody (H-7): m-IgGκ BP-HRP Bundle | sc-522399 | 200 µg Ab, 40 µg BP | $354.00 | |||
Nup88 Antibody (H-7): m-IgG2b BP-HRP Bundle | sc-549027 | 200 µg Ab; 10 µg BP | $354.00 | |||
Nup88 Antibody (H-7) AC | sc-365868 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Nup88 Antibody (H-7) HRP | sc-365868 HRP | 200 µg/ml | $316.00 | |||
Nup88 Antibody (H-7) FITC | sc-365868 FITC | 200 µg/ml | $330.00 | |||
Nup88 Antibody (H-7) PE | sc-365868 PE | 200 µg/ml | $343.00 | |||
Nup88 Antibody (H-7) Alexa Fluor® 488 | sc-365868 AF488 | 200 µg/ml | $357.00 | |||
Nup88 Antibody (H-7) Alexa Fluor® 546 | sc-365868 AF546 | 200 µg/ml | $357.00 | |||
Nup88 Antibody (H-7) Alexa Fluor® 594 | sc-365868 AF594 | 200 µg/ml | $357.00 | |||
Nup88 Antibody (H-7) Alexa Fluor® 647 | sc-365868 AF647 | 200 µg/ml | $357.00 | |||
Nup88 Antibody (H-7) Alexa Fluor® 680 | sc-365868 AF680 | 200 µg/ml | $357.00 | |||
Nup88 Antibody (H-7) Alexa Fluor® 790 | sc-365868 AF790 | 200 µg/ml | $357.00 |