Nulp1 Antibody (A-6): sc-514203
- Nulp1 Antibody (A-6) is a mouse monoclonal IgG1 κ Nulp1 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 140-163 within an internal region of Nulp1 of human origin
- Nulp1 Antibody (A-6) is recommended for detection of Nulp1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Nulp1 Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-514203 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Nulp1 Antibody (A-6) for WB applications. These reagents are now offered in bundles with Nulp1 Antibody (A-6) (see ordering information below).
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Nulp1 Antibody (A-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Nulp1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nulp1 (A-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Nulp1, also known as nuclear localized protein 1 or transcription factor 25, is a 676 amino acid protein that plays a crucial role in regulating cell death, making Nulp1 significant in developmental processes and disease states. Nulp1 is primarily localized in the nucleus, where Nulp1 is involved in transcriptional repression, particularly of serum response factor (SRF), and also interacts with X-linked inhibitor of apoptosis protein (XIAP), which is important for apoptosis regulation. Nuclear localization of Nulp1 is vital for function in gene expression modulation, and cytosolic presence suggests additional roles in cellular signaling pathways. Nulp1 is widely expressed, with particularly high levels found in the embryonic brain and adult heart, indicating significance in both development and cardiac function. The gene encoding Nulp1 is located on human chromosome 16, a region associated with several genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome, highlighting potential implications in various pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Nulp1 Antibody (A-6) References:
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | Kikuno, R., et al. 1999. DNA Res. 6: 197-205. PMID: 10470851
- The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy. | Bomont, P., et al. 2000. Nat Genet. 26: 370-4. PMID: 11062483
- Nulp1, a novel basic helix-loop-helix protein expressed broadly during early embryonic organogenesis and prominently in developing dorsal root ganglia. | Olsson, M., et al. 2002. Cell Tissue Res. 308: 361-70. PMID: 12107429
- Genetics of inflammatory bowel disease: progress and prospects. | Mathew, CG. and Lewis, CM. 2004. Hum Mol Genet. 13 Spec No 1: R161-8. PMID: 14764625
- Advances in the genetics of inflammatory bowel disease. | Cho, JH. 2004. Curr Gastroenterol Rep. 6: 467-73. PMID: 15527676
- hnulp1, a basic helix-loop-helix protein with a novel transcriptional repressive domain, inhibits transcriptional activity of serum response factor. | Cai, Z., et al. 2006. Biochem Biophys Res Commun. 343: 973-81. PMID: 16574069
- Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein. | Steen, H. and Lindholm, D. 2008. Biochem Biophys Res Commun. 366: 432-7. PMID: 18068114
- The Rubinstein-Taybi syndrome: occurrence in two sets of identical twins. | Baraitser, M. and Preece, MA. 1983. Clin Genet. 23: 318-20. PMID: 6682729
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nulp1 Antibody (A-6) | sc-514203 | 200 µg/ml | $322.00 | |||
Nulp1 Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-531063 | 200 µg Ab; 10 µg BP | $361.00 | |||
Nulp1 Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-524646 | 200 µg Ab, 40 µg BP | $361.00 | |||
Nulp1 Antibody (A-6): m-IgG1 BP-HRP Bundle | sc-544380 | 200 µg Ab; 20 µg BP | $361.00 | |||
Nulp1 Antibody (A-6) X | sc-514203 X | 200 µg/0.1 ml | $322.00 | |||
Nulp1 Antibody (A-6) AC | sc-514203 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Nulp1 Antibody (A-6) HRP | sc-514203 HRP | 200 µg/ml | $322.00 | |||
Nulp1 Antibody (A-6) FITC | sc-514203 FITC | 200 µg/ml | $336.00 | |||
Nulp1 Antibody (A-6) PE | sc-514203 PE | 200 µg/ml | $349.00 | |||
Nulp1 Antibody (A-6) Alexa Fluor® 488 | sc-514203 AF488 | 200 µg/ml | $364.00 | |||
Nulp1 Antibody (A-6) Alexa Fluor® 546 | sc-514203 AF546 | 200 µg/ml | $364.00 | |||
Nulp1 Antibody (A-6) Alexa Fluor® 594 | sc-514203 AF594 | 200 µg/ml | $364.00 | |||
Nulp1 Antibody (A-6) Alexa Fluor® 647 | sc-514203 AF647 | 200 µg/ml | $364.00 | |||
Nulp1 Antibody (A-6) Alexa Fluor® 680 | sc-514203 AF680 | 200 µg/ml | $364.00 | |||
Nulp1 Antibody (A-6) Alexa Fluor® 790 | sc-514203 AF790 | 200 µg/ml | $364.00 | |||
Nulp1 (A-6) Neutralizing Peptide | sc-514203 P | 100 µg/0.5 ml | $69.00 |