Nucleostemin Antibody (F-5): sc-398978

Nucleostemin Antibody (F-5) is a mouse monoclonal IgG1 antibody that detects Nucleostemin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nucleostemin, also known as Nucleolar GTP-binding protein 3, plays a crucial role in the regulation of cell proliferation, particularly in stem cells, where anti-Nucleostemin antibody (F-5) shows predominant expression in the nucleoli of adult central nervous system stem cells, primitive bone marrow cells, and embryonic stem cells, as well as in various cancer cell lines. Nucleostemin is essential for maintaining the proliferative capacity of stem cells, as overexpression or depletion can significantly impact cell growth. Nucleostemin shuttles between the nucleus and the nucleolus, indicating involvement in critical cellular processes. Notably, the gene encoding Nucleostemin is located on chromosome 3p21.1, and dysregulation has been linked to the growth regulation of several cancers, including liver and gastric cancer, highlighting importance as a potential therapeutic target. Nucleostemin monoclonal antibody (F-5) serves as a valuable tool for researchers investigating stem cell biology and cancer progression.

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Nucleostemin Antibody (F-5) References:

1. Expression of nucleostemin in prostate cancer and its effect on the proliferation of PC-3 cells.  |  Liu, RL., et al. 2008. Chin Med J (Engl). 121: 299-304. PMID: 18304460
2. A nucleolar weapon in our fight for regenerating adult hearts: nucleostemin and cardiac stem cells.  |  Tjwa, M. and Dimmeler, S. 2008. Circ Res. 103: 4-6. PMID: 18596260
3. Nucleolar modulation of TRF1: a dynamic way to regulate telomere and cell cycle by nucleostemin and GNL3L.  |  Tsai, RY. 2009. Cell Cycle. 8: 2912-6. PMID: 19713769
4. Clinical significance of nucleostemin expression and its correlation with cyclin D1 expression in malignant ovarian tumors.  |  Lin, S. and Yu, HS. 2011. Int J Gynecol Cancer. 21: 1166-71. PMID: 21892090
5. Nucleostemin and TWIST as predictive markers for recurrence after neoadjuvant chemotherapy for esophageal carcinoma.  |  Nakajima, TE., et al. 2012. Cancer Sci. 103: 233-8. PMID: 22050045
6. Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells.  |  Meng, L., et al. 2013. Proc Natl Acad Sci U S A. 110: 11415-20. PMID: 23798389
7. Nucleostemin expression in invasive breast cancer.  |  Kobayashi, T., et al. 2014. BMC Cancer. 14: 215. PMID: 24650343
8. Knockdown of Nucleostemin in an ovarian cancer SKOV-3 cell line and its effects on cell malignancy.  |  Wang, J., et al. 2017. Biochem Biophys Res Commun. 487: 262-267. PMID: 28412352
9. Nucleostemin promotes hepatocellular carcinoma by regulating the function of STAT3.  |  Zhang, X., et al. 2020. Exp Cell Res. 387: 111748. PMID: 31785228
10. Proteomic Investigation of the Role of Nucleostemin in Nucleophosmin-Mutated OCI-AML 3 Cell Line.  |  Cela, I., et al. 2022. Int J Mol Sci. 23: PMID: 35886999

The preferred Nucleostemin antibody is Nucleostemin Antibody (E-8): sc-166460.