Nucleostemin Antibody (A-8): sc-166430
- Nucleostemin Antibody (A-8) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 269-538 mapping at the C-terminus of Nucleostemin of mouse origin
- recommended for detection of Nucleostemin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for Nucleostemin Antibody (A-8) for WB and IHC(P) applications. These reagents are now offered in bundles with Nucleostemin Antibody (A-8) (see ordering information below).
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Nucleostemin Antibody (A-8) is a mouse monoclonal IgG2b antibody that detects Nucleostemin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Nucleostemin, also known as Nucleolar GTP-binding protein 3, plays a crucial role in the regulation of cell proliferation, particularly in stem cells, where anti-Nucleostemin antibody (A-8) shows predominant expression in the nucleoli of adult central nervous system stem cells, primitive bone marrow cells, and embryonic stem cells, as well as in several cancer cell lines. Nucleostemin is essential for maintaining the proliferative capacity of stem cells, as overexpression or depletion can significantly impact cell growth. Nucleostemin shuttles between the nucleus and the nucleolus, highlighting a dynamic role in cellular processes. Notably, the gene encoding Nucleostemin is located on chromosome 3p21.1, and involvement in the growth regulation of various cancers, including liver and gastric cancer, underscores importance in cancer biology. Nucleostemin′s interaction with specific proteins involved in cell cycle regulation further emphasizes significance in both normal and pathological states, making Nucleostemin (A-8) antibody a valuable tool for researchers studying stem cell biology and cancer.
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Nucleostemin Antibody (A-8) References:
- Multiple controls regulate nucleostemin partitioning between nucleolus and nucleoplasm. | Meng, L., et al. 2006. J Cell Sci. 119: 5124-36. PMID: 17158916
- Critical role of nucleostemin in pre-rRNA processing. | Romanova, L., et al. 2009. J Biol Chem. 284: 4968-77. PMID: 19106111
- Nucleostemin in injury-induced liver regeneration. | Shugo, H., et al. 2012. Stem Cells Dev. 21: 3044-54. PMID: 22775537
- Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells. | Yamashita, M., et al. 2013. Biochem Biophys Res Commun. 441: 196-201. PMID: 24140061
- Nucleostemin and ASPP2 expression is correlated with pituitary adenoma proliferation. | Ma, L., et al. 2013. Oncol Lett. 6: 1313-1318. PMID: 24179515
- Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively. | Lin, T., et al. 2014. J Cell Sci. 127: 2302-12. PMID: 24610951
- Nucleostemin promotes the proliferation of human glioma via Wnt/β-Catenin pathway. | Bao, Z., et al. 2016. Neuropathology. 36: 237-49. PMID: 26607678
- High nucleostemin expression has a favorable prognostic effect on gastric carcinomas. | Yıldırım, GD., et al. 2018. Turk J Med Sci. 48: 484-490. PMID: 29914242
- Expression of nucleostemin in odontogenic cysts and tumors. | Andisheh-Tadbir, A., et al. 2020. Exp Mol Pathol. 113: 104376. PMID: 31926976
- Nucleostemin interacts with SMAD3 promoting tumor metastasis. | Sun, X., et al. 2025. Exp Cell Res. 444: 114362. PMID: 39662660
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nucleostemin Antibody (A-8) | sc-166430 | 200 µg/ml | $322.00 | |||
Nucleostemin Antibody (A-8): m-IgG Fc BP-HRP Bundle | sc-540103 | 200 µg Ab; 10 µg BP | $361.00 | |||
Nucleostemin Antibody (A-8): m-IgG2b BP-HRP Bundle | sc-549774 | 200 µg Ab; 10 µg BP | $361.00 |