nucleobindin Antibody (R-Y2): sc-100793
- nucleobindin Antibody (R-Y2) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant nucleobindin of human origin
- recommended for detection of nucleobindin of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for nucleobindin Antibody (R-Y2). This work is in progress.
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Nucleobindin Antibody (R-Y2) is a mouse monoclonal IgG1 antibody that detects nucleobindin in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Nucleobindin, also known as Nuc or Calnuc, is a secreted protein that plays a crucial role in the immune response, particularly in producing DNA-specific antibodies in lupus-prone MRL/lpr mice. Anti-nucleobindin antibody (R-Y2) recognizes a protein characterized by a signal peptide, two EF-hand motifs, and a leucine-zipper motif, enabling calcium binding and DNA interaction. The presence of two calcium-binding domains allows nucleobindin to function as a major Golgi Ca2+ binding protein, essential for maintaining calcium homeostasis within cells. Localization to the cis-Golgi network and association with membranes of polarized cells highlight nucleobindin′s importance in cellular signaling and trafficking processes. Nucleobindin′s involvement in autoimmunity, apoptosis, and calcium regulation in bone matrix underscores its significance in both health and disease, making nucleobindin monoclonal antibody (R-Y2) a valuable tool for studying these critical biological pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
nucleobindin Antibody (R-Y2) | sc-100793 | 100 µg/ml | $339.00 |