NSUN6 Antibody (D-5): sc-393446

NSUN6 Antibody (D-5) is a mouse monoclonal IgM antibody that detects NSUN6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-NSUN6 antibody (D-5) is available as the non-conjugated form. NSUN6, also known as NOL1/NOP2/Sun domain family member 6, plays a vital role in the nucleolus, which is essential for ribosome assembly and the maintenance of nucleolar structure. This 469 amino acid protein belongs to the methyltransferase superfamily and contains a PUA domain, suggesting a potential S-adenosyl-L-methionine-dependent methyltransferase activity. NSUN6 is encoded on human chromosome 10, a region that harbors over 1,200 genes and accounts for nearly 4.5% of the human genome. Notably, defects in genes mapping to this chromosome have been linked to various genetic disorders, including Charcot-Marie-Tooth disease and multiple endocrine neoplasia type 2. Understanding NSUN6 function is crucial, as NSUN6 may influence ribosomal RNA methylation, thereby impacting protein synthesis and cellular function.

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NSUN6 Antibody (D-5) References:

1. Report of the third international workshop on human chromosome 10 mapping and sequencing 1999.  |  Deloukas, P., et al. 2000. Cytogenet Cell Genet. 90: 1-12. PMID: 11060438
2. The DNA sequence and comparative analysis of human chromosome 10.  |  Deloukas, P., et al. 2004. Nature. 429: 375-81. PMID: 15164054
3. Comparative mapping of human chromosome 10 to pig chromosomes 10 and 14.  |  Nonneman, D. and Rohrer, GA. 2004. Anim Genet. 35: 338-43. PMID: 15265077
4. Aurora-B regulates RNA methyltransferase NSUN2.  |  Sakita-Suto, S., et al. 2007. Mol Biol Cell. 18: 1107-17. PMID: 17215513
5. First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity.  |  Cho, MY., et al. 2008. Am J Surg Pathol. 32: 1258-64. PMID: 18594467
6. Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen.  |  Henríquez, R., et al. 1990. J Biol Chem. 265: 2209-15. PMID: 2298745

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NSUN6 Antibody (D-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-NSUN6 Antibody (D-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NSUN6 Antibody (D-5) Specifications

Alternate Product Name: NSUN6

Product Clone Name: D-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 388-402

Epitope Target: NSUN6

Epitope Species: human

Product Reactivity/Detection: NSUN6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for NSUN6 Antibody (D-5): P: Blocking Peptide, X: TransCruz Reagent