NRAGE Antibody (AK47): sc-130434
- NRAGE Antibody (AK47) is a mouse monoclonal IgG2b κ NRAGE antibody, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant NRAGE of human origin
- recommended for detection of NRAGE of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NRAGE Antibody (AK47). This work is in progress.
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NRAGE Antibody (AK47) is a mouse monoclonal IgG2b kappa light chain antibody that detects NRAGE protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-NRAGE antibody (AK47) is available as the non-conjugated monoclonal isotype antibody. NRAGE protein, a member of the neurotrophin receptor-interacting MAGE homolog family, plays a crucial role in neuronal development and survival by interacting with the p75 neurotrophin receptor. Upon binding of nerve growth factor (NGF) to p75NTR, NRAGE translocates to the plasma membrane, where NRAGE influences critical signaling pathways that regulate neuronal differentiation and apoptosis. This interaction is vital for proper functioning of sympathetic neuron precursor cells, as overexpression of NRAGE can lead to cell cycle arrest and promote NGF-dependent apoptosis, highlighting NRAGE′s importance in neuronal health and development. NRAGE is expressed in the medulla oblongata during development and in motor neurons, suggesting NRAGE′s significant role in the central nervous system. The structural similarities between NRAGE and other MAGE proteins, such as necdin, indicate that these proteins may share common mechanisms in mediating cell cycle effects, further emphasizing NRAGE′s importance in neurobiology and potential implications in neurodegenerative diseases.
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NRAGE Antibody (AK47) References:
- Neurotrophins and synaptic plasticity. | McAllister, AK., et al. 1999. Annu Rev Neurosci. 22: 295-318. PMID: 10202541
- Neurotrophin actions during the development of the peripheral nervous system. | Fariñas, I. Microsc Res Tech. 45: 233-42. PMID: 10383116
- Expression of MAGE, GAGE and BAGE genes in human liver diseases: utility as molecular markers for hepatocellular carcinoma. | Kobayashi, Y., et al. 2000. J Hepatol. 32: 612-7. PMID: 10782910
- Immunoreactivity with the anti-MAGE antibody 57B in malignant melanoma: frequency of expression and correlation with prognostic parameters. | Busam, KJ., et al. 2000. Mod Pathol. 13: 459-65. PMID: 10786815
- Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines. | Klein, C., et al. 2000. J Exp Med. 191: 1699-708. PMID: 10811863
- Melanoma antigen genes 1 and 2 are differentially expressed in human gastric and cardial carcinomas. | Granelli, P., et al. 2000. Scand J Gastroenterol. 35: 528-33. PMID: 10868457
- Genetic detection for micrometastasis in lymph node of biliary tract carcinoma. | Okami, J., et al. 2000. Clin Cancer Res. 6: 2326-32. PMID: 10873083
- NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis. | Salehi, AH., et al. 2000. Neuron. 27: 279-88. PMID: 10985348
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NRAGE Antibody (AK47) | sc-130434 | 100 µg/ml | $339.00 |