NPY1-R Antibody (E-4): sc-393192

NPY1-R Antibody (E-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects NPY1-R protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NPY1-R (E-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The NPY1-R gene, located on human chromosome 4q32, encodes a 384 amino acid protein known as Neuropeptide Y receptor Y1, which is a member of the G-protein-coupled receptor superfamily characterized by seven putative transmembrane domains. Notably, the NPY1-R gene is unique among its family as it consists of three exons, contrasting with the contiguous structure of other G-protein-coupled receptor genes. NPY1-R is predominantly expressed in the postsynaptic membranes of various tissues, including the spleen, small intestine, kidney, testis, placenta, aortic smooth muscle, and throughout the central nervous system, highlighting its critical role in diverse physiological processes. This receptor interacts with Neuropeptide Y and unphosphorylated Peptide YY (PYY), with a particularly strong association with phosphorylated PYY. Depending on the cell type, NPY1-R couples with different G proteins, which serve as second messengers, and activation is essential for the release of substance P, a neurotransmitter involved in pain signaling, as well as the initiation of neurogenic inflammation. Furthermore, NPY1-R plays a significant role in stimulating feeding behaviors through interaction with Neuropeptide Y, making NPY1-R a vital target for research in metabolic and neuropsychiatric disorders.

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NPY1-R Antibody (E-4) References:

1. Immunohistochemical localization of the neuropeptide Y Y1 receptor in rat central nervous system.  |  Migita, K., et al. 2001. Brain Res. 889: 23-37. PMID: 11166683
2. A typical Y1 receptor regulates feeding behaviors: effects of a potent and selective Y1 antagonist, J-115814.  |  Kanatani, A., et al. 2001. Mol Pharmacol. 59: 501-5. PMID: 11179445
3. Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor.  |  Naveilhan, P., et al. 2001. Nature. 409: 513-7. PMID: 11206547
4. Ser(13)-phosphorylated PYY from porcine intestine with a potent biological activity.  |  Chen, Z., et al. 2001. FEBS Lett. 492: 119-22. PMID: 11248248
5. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.  |  Larhammar, D., et al. 1992. J Biol Chem. 267: 10935-8. PMID: 1317848
6. Cloned human neuropeptide Y receptor couples to two different second messenger systems.  |  Herzog, H., et al. 1992. Proc Natl Acad Sci U S A. 89: 5794-8. PMID: 1321422
7. NPY receptors in human cancer: a review of current knowledge.  |  Körner, M. and Reubi, JC. 2007. Peptides. 28: 419-25. PMID: 17223228
8. NPY and brain monoamines in the pathogenesis of cancer anorexia.  |  Laviano, A., et al. 2008. Nutrition. 24: 802-5. PMID: 18662859
9. Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer.  |  Desai, D. and Shende, P. 2020. Curr Protein Pept Sci. 21: 1097-1102. PMID: 32951575
10. NPY and Gene Therapy for Epilepsy: How, When,.. and Y.  |  Cattaneo, S., et al. 2020. Front Mol Neurosci. 13: 608001. PMID: 33551745
11. Atractylodin alleviates cancer anorexia-cachexia syndrome by regulating NPY through hypothalamic Sirt1/AMPK axis-induced autophagy.  |  Yu, B., et al. 2022. Biochem Biophys Res Commun. 625: 154-160. PMID: 35963161
12. Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor.  |  Herzog, H., et al. 1993. J Biol Chem. 268: 6703-7. PMID: 8095935

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NPY1-R Antibody (E-4) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-NPY1-R Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NPY1-R Antibody (E-4) Specifications

Alternate Product Name: NPY1-R

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 181-271

Epitope Target: NPY1-R

Epitope Species: human

Product Reactivity/Detection: NPY1-R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for NPY1-R Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin