NP2 Antibody (G-9): sc-166035
- NP2 Antibody (G-9) is a mouse monoclonal IgG1 κ NP2 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 382-431 mapping at the C-terminus of NP2 of human origin
- NP2 Antibody (G-9) is recommended for detection of NP2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine
- Anti-NP2 Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for NP2 Antibody (G-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with NP2 Antibody (G-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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NP2 Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects NP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NP2 (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NP2 belongs to the long pentraxin family, playing a crucial role in the central nervous system, particularly in the brain, where NP2 forms multimeric complexes essential for neuronal communication and synaptic plasticity - processes vital for learning and memory. NP2, located on chromosome 7q22.1, shares structural similarities with neuronal pentraxin 1 (NP1) and neuronal pentraxin receptor (NPR), both implicated in synaptic material uptake. While NP2′s exact function remains under investigation, NP2 contains several potential N-linked glycosylation sites, potentially influencing stability, localization, and protein interactions. NPR, expressed on the cell membrane, forms heteropentamers with NP1 and NP2, facilitating release from the membrane through proteolytic processes, thereby modulating synaptic activity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NP2 Antibody (G-9) References:
- Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. | Kirkpatrick, LL., et al. 2000. J Biol Chem. 275: 17786-92. PMID: 10748068
- No association between the neuronal pentraxin II gene polymorphism and autism. | Marui, T., et al. 2007. Prog Neuropsychopharmacol Biol Psychiatry. 31: 940-3. PMID: 17408830
- Quantitative analysis of NPTX2 hypermethylation is a promising molecular diagnostic marker for pancreatic cancer. | Park, JK., et al. 2007. Pancreas. 35: e9-15. PMID: 17895837
- Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. | Moran, LB., et al. 2008. Acta Neuropathol. 115: 471-8. PMID: 17987278
- Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. | Hsu, YC. and Perin, MS. 1995. Genomics. 28: 220-7. PMID: 8530029
- Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. | Dodds, DC., et al. 1997. J Biol Chem. 272: 21488-94. PMID: 9261167
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NP2 Antibody (G-9) | sc-166035 | 200 µg/ml | $322.00 | |||
NP2 Antibody (G-9): m-IgGκ BP-HRP Bundle | sc-521491 | 200 µg Ab, 40 µg BP | $361.00 | |||
NP2 Antibody (G-9) AC | sc-166035 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NP2 Antibody (G-9) HRP | sc-166035 HRP | 200 µg/ml | $322.00 | |||
NP2 Antibody (G-9) FITC | sc-166035 FITC | 200 µg/ml | $336.00 | |||
NP2 Antibody (G-9) PE | sc-166035 PE | 200 µg/ml | $349.00 | |||
NP2 Antibody (G-9) Alexa Fluor® 488 | sc-166035 AF488 | 200 µg/ml | $364.00 | |||
NP2 Antibody (G-9) Alexa Fluor® 546 | sc-166035 AF546 | 200 µg/ml | $364.00 | |||
NP2 Antibody (G-9) Alexa Fluor® 594 | sc-166035 AF594 | 200 µg/ml | $364.00 | |||
NP2 Antibody (G-9) Alexa Fluor® 647 | sc-166035 AF647 | 200 µg/ml | $364.00 | |||
NP2 Antibody (G-9) Alexa Fluor® 680 | sc-166035 AF680 | 200 µg/ml | $364.00 | |||
NP2 Antibody (G-9) Alexa Fluor® 790 | sc-166035 AF790 | 200 µg/ml | $364.00 |