nov Antibody (F-7): sc-136968

nov Antibody (F-7) is a mouse monoclonal IgG2b antibody that detects nov in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). nov, also known as nephroblastoma overexpressed, CCN3, or NOVH, plays a crucial role in regulating cellular processes, particularly in tissues where calcium is a significant factor, including the adrenal gland, central nervous system, bone and cartilage, heart muscle, and kidney. nov (F-7) antibody′s target inhibits myoblast differentiation via the Notch signaling pathway, highlighting nov′s importance in muscle development and regeneration, as well as potential implications in various pathologies, including tumorigenesis. nov′s interaction with the Notch1 extracellular domain underscores nov′s role as a negative regulator of cell growth, contrasting with other members of the CCN family that promote proliferation. The gene encoding nov is located on human chromosome 8q24.12 and was initially identified through its avian homolog in studies of virally induced nephroblastoma, making nov a significant focus for research into cancer biology and therapeutic interventions. With diverse applications and critical biological functions, anti-nov antibody (F-7) serves as an essential tool for researchers investigating the complexities of cell signaling and disease mechanisms.

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nov Antibody (F-7) References:

1. Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation.  |  Liu, C., et al. 1999. Gene. 238: 471-8. PMID: 10570975
2. Aberrant expression of Cyr61, a member of the CCN (CTGF/Cyr61/Cef10/NOVH) family, and dysregulation by 17 beta-estradiol and basic fibroblast growth factor in human uterine leiomyomas.  |  Sampath, D., et al. 2001. J Clin Endocrinol Metab. 86: 1707-15. PMID: 11297607
3. CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma.  |  Vallacchi, V., et al. 2008. Cancer Res. 68: 715-23. PMID: 18245471
4. Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis.  |  Canalis, E., et al. 2010. Endocrinology. 151: 221-33. PMID: 19934377
5. Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathways.  |  Huang, CY., et al. 2011. Biochem Pharmacol. 81: 577-85. PMID: 21145881
6. Nephroblastoma overexpressed (Nov) induces gremlin in ST-2 stromal cell lines by post-transcriptional mechanisms.  |  Smerdel-Ramoya, A., et al. 2011. J Cell Biochem. 112: 715-22. PMID: 21268093
7. Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells.  |  Zhang, Y. and Wang, C. 2011. Oncogene. 30: 3549-62. PMID: 21423212
8. Nephroblastoma overexpressed gene (NOV) enhances RCC cell motility through upregulation of ICAM-1 and COX-2 expression via Akt pathway.  |  Liu, S., et al. 2015. Int J Clin Exp Pathol. 8: 1302-11. PMID: 25973014
9. Nephroblastoma overexpressed gene expression and its prognostic implications of clinical outcomes in renal cell carcinoma patients.  |  Shi, H., et al. 2017. Cancer Biomark. 20: 241-246. PMID: 28800310
10. CCN3/Nephroblastoma Overexpressed Is a Functional Mediator of Prostate Cancer Bone Metastasis That Is Associated with Poor Patient Prognosis.  |  Dankner, M., et al. 2019. Am J Pathol. 189: 1451-1461. PMID: 31202437

The preferred nov antibody is nov Antibody (D-9): sc-136967.