nov Antibody (F-11): sc-136965

nov Antibody (F-11) is a mouse monoclonal IgG2b antibody that detects nov in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). nov, also known as nephroblastoma overexpressed, CCN3, or NOVH, plays a crucial role in regulating cellular processes, particularly in tissues where calcium is a significant factor, such as the adrenal gland, central nervous system, bone and cartilage, heart muscle, and kidney. nov (F-11) antibody recognizes a unique member of the CCN family that serves as a negative regulator of cell growth, contrasting with its counterparts, Cyr61 and CTGF, which promote cell proliferation. nov′s ability to inhibit myoblast differentiation through interaction with the Notch1 extracellular domain highlights nov′s importance in developmental biology and tissue homeostasis. Aberrant expression of nov has been linked to tumorigenesis, making nov a critical focus for understanding cancer biology. The gene encoding nov is located on human chromosome 8q24.12 and was initially identified due to its overexpression in virally induced nephroblastoma, underscoring nov′s relevance in both normal physiology and disease states. With diverse applications and significant biological implications, anti-nov antibody (F-11) serves as an essential tool for researchers investigating the roles of CCN proteins in health and disease.

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nov Antibody (F-11) References:

1. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.  |  Brigstock, DR. 1999. Endocr Rev. 20: 189-206. PMID: 10204117
2. NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues.  |  Perbal, B. 2001. Mol Pathol. 54: 57-79. PMID: 11322167
3. Altered expression of novH is associated with human adrenocortical tumorigenesis.  |  Martinerie, C., et al. 2001. J Clin Endocrinol Metab. 86: 3929-40. PMID: 11502835
4. The expression of novH in adrenocortical cells is down-regulated by TGFbeta 1 through c-Jun in a Smad-independent manner.  |  Lafont, J., et al. 2002. J Biol Chem. 277: 41220-9. PMID: 12149257
5. NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism.  |  Laurent, M., et al. 2003. FASEB J. 17: 1919-21. PMID: 14519668
6. Differential expression of novH and CTGF in human glioma cell lines.  |  Xin, LW., et al. 1996. Clin Mol Pathol. 49: M91-7. PMID: 16696057
7. Nephroblastoma overexpressed (Nov) is a novel bone morphogenetic protein antagonist.  |  Canalis, E. 2007. Ann N Y Acad Sci. 1116: 50-8. PMID: 18083920
8. Clinical Significance of Expression of Nephroblastoma Overexpressed (NOV) in Patients with Colorectal Cancer.  |  Ueda, M., et al. 2015. Anticancer Res. 35: 6591-7. PMID: 26637874
9. Nephroblastoma overexpressed protein (NOV) enhances 5-Fu-mediated inhibitory effect of colorectal cancer cell proliferation via JNK/AP-1/caspase-8/caspase-3 pathway.  |  Wang, D., et al. 2021. Discov Oncol. 12: 10. PMID: 35201461
10. The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling.  |  Perbal, B., et al. 1999. Proc Natl Acad Sci U S A. 96: 869-74. PMID: 9927660

The preferred nov antibody is nov Antibody (D-9): sc-136967.