NOPE Antibody (27L-2): sc-100280
- NOPE Antibody (27L-2) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant NOPE of human origin
- recommended for detection of NOPE of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NOPE Antibody (27L-2). This work is in progress.
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NOPE Antibody (27L-2) is a mouse monoclonal IgG2a antibody that detects NOPE in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). NOPE, or neighbor of punc E11, is a 1250 amino acid protein that plays a crucial role in embryonic development and cell adhesion, being a member of the immunoglobulin superfamily alongside other significant proteins like Deleted in Colorectal Cancer (DCC). NOPE is characterized by five fibronectin type-III repeats and four immunoglobulin-like C2-type repeats, which are essential for mediating cell-cell interactions and promoting cellular differentiation during embryogenesis. NOPE expression is particularly prominent in the notochord, skeletal muscle, and the ventricular zone of the nervous system during development, and remains present in the hippocampus of the adult brain, indicating potential involvement in neurodevelopmental processes and synaptic plasticity. NOPE′s unique structural features, especially its diverged cytoplasmic domain compared to its homolog Punc, suggest interactions with specific intracellular signaling pathways, further underscoring importance in both developmental biology and potential implications in neurological research. Anti-NOPE antibody (27L-2) serves as an invaluable tool for researchers exploring functional dynamics in various biological contexts.
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NOPE Antibody (27L-2) References:
- New cell surface markers for murine fetal hepatic stem cells identified through high density complementary DNA microarrays. | Nierhoff, D., et al. 2007. Hepatology. 46: 535-47. PMID: 17508344
- Neighbor of Punc E11, a novel oncofetal marker for hepatocellular carcinoma. | Marquardt, JU., et al. 2011. Int J Cancer. 128: 2353-63. PMID: 20658536
- Expression of neighbor of Punc E11 in hepatocarcinogenesis induced by diethylnitrosamine. | Kim, YH., et al. 2014. Oncol Rep. 32: 1043-9. PMID: 24969048
- Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation. | Baggio, F., et al. 2014. Nucleic Acids Res. 42: 13920-38. PMID: 25428350
- Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress. | Jaiswal, M., et al. 2015. PLoS Biol. 13: e1002197. PMID: 26176594
- Depolarized Hepatocytes Express the Stem/Progenitor Cell Marker Neighbor of Punc E11 After Bile Duct Ligation in Mice. | Bowe, A., et al. 2018. J Histochem Cytochem. 66: 563-576. PMID: 29624127
- First evaluation of Neighbor of Punc E11 (NOPE) as a novel marker in human hepatocellular carcinoma. | Zweerink, S., et al. 2021. Cancer Biomark. 30: 75-83. PMID: 32986656
- Expression of Neighbor of Punc E11 (NOPE) in early stage esophageal adenocarcinoma is associated with reduced survival. | Kütting, F., et al. 2022. Sci Rep. 12: 3584. PMID: 35246597
- Repolarization Precedes Oval Cell-mediated Hepatocytic Regeneration in the CDE Diet Mouse Model. | Zweerink, S., et al. 2022. J Histochem Cytochem. 70: 377-389. PMID: 35272516
- Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC. | Cheramangalam, RN., et al. 2023. PLoS Genet. 19: e1010493. PMID: 37098042
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NOPE Antibody (27L-2) | sc-100280 | 100 µg/ml | $333.00 |