NMDAε1 Antibody (D-8): sc-390094
- NMDAε1 Antibody (D-8) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 31-69 within an N-terminal extracellular domain of NMDAε1 of human origin
- recommended for detection of NMDAε1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for NMDAε1 Antibody (D-8) for WB applications. This reagent is now offered in a bundle with NMDAε1 Antibody (D-8) (see ordering information below).
NMDAε1 Antibody (D-8) is a mouse monoclonal IgG1 antibody that detects NMDAε1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NMDAε1 is a critical subunit of the NMDA receptor, which plays a pivotal role in synaptic plasticity and memory function in the central nervous system. This subunit contributes to the receptor′s unique properties, including voltage-dependent activation and high permeability to calcium ions, which are essential for various signaling pathways involved in neuronal communication and plasticity. The NMDA receptor, composed of multiple subunits including ε1, ε2, ε3, ε4, and the ζ subunit, is strategically located in the postsynaptic membrane of neurons, where NMDAε1 mediates excitatory neurotransmission. NMDAε1′s presence in the brainstem and limited distribution among the epsilon subunits highlight specialized functions in different neural circuits, making NMDAε1 a valuable target for studying neurodevelopmental and neurodegenerative disorders. Anti-NMDAε1 antibody (D-8) serves as an essential tool for researchers investigating the complex mechanisms of synaptic transmission and plasticity, as well as the pathophysiology of various neurological conditions.
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NMDAε1 Antibody (D-8) References:
- NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. | Autry, AE., et al. 2011. Nature. 475: 91-5. PMID: 21677641
- Structure, function, and pharmacology of NMDA receptor channels. | Vyklicky, V., et al. 2014. Physiol Res. 63: S191-203. PMID: 24564659
- The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment. | Balu, DT. 2016. Adv Pharmacol. 76: 351-82. PMID: 27288082
- Unconventional NMDA Receptor Signaling. | Dore, K., et al. 2017. J Neurosci. 37: 10800-10807. PMID: 29118208
- Encephalitis associated with antibodies against the NMDA receptor. | Guasp, M. and Dalmau, J. 2018. Med Clin (Barc). 151: 71-79. PMID: 29183618
- The origin of NMDA receptor hypofunction in schizophrenia. | Nakazawa, K. and Sapkota, K. 2020. Pharmacol Ther. 205: 107426. PMID: 31629007
- Ion flux-independent NMDA receptor signaling. | Park, DK., et al. 2022. Neuropharmacology. 210: 109019. PMID: 35278420
- Mechanisms of NMDA receptor regulation. | Mony, L. and Paoletti, P. 2023. Curr Opin Neurobiol. 83: 102815. PMID: 37988826
- Trans-synaptic molecular context of NMDA receptor nanodomains. | Anderson, MC., et al. 2023. bioRxiv.. PMID: 38187545
- Ketamine alleviates NMDA receptor hypofunction through synaptic trapping. | Villéga, F., et al. 2024. Neuron. 112: 3311-3328.e9. PMID: 39047728
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NMDAε1 Antibody (D-8) | sc-390094 | 200 µg/ml | $322.00 | |||
NMDAε1 Antibody (D-8): m-IgG Fc BP-HRP Bundle | sc-540756 | 200 µg Ab; 10 µg BP | $361.00 | |||
NMDAε1 (D-8) Neutralizing Peptide | sc-390094 P | 100 µg/0.5 ml | $69.00 |