Nlk Antibody (H-2): sc-271323
- Nlk Antibody (H-2) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against a peptide mapping at the C-terminus of Nlk of mouse origin
- recommended for detection of Nlk of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Nlk Antibody (H-2) for WB applications. These reagents are now offered in bundles with Nlk Antibody (H-2) (see ordering information below).
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Nlk Antibody (H-2) is a mouse monoclonal IgG2b antibody that detects Nlk in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nlk, or nemo-like kinase, plays a crucial role in various cellular processes, particularly in the regulation of gene expression and cell signaling pathways. Nlk is primarily located in the nucleus, where Nlk influences transcriptional regulation and cellular responses to stress and growth signals. Nuclear localization of Nlk is significant because Nlk can interact directly with transcription factors and other nuclear proteins, thereby modulating their activity and impacting cellular outcomes such as proliferation, differentiation, and apoptosis. Nlk′s ability to autophosphorylate further enhances functional versatility, enabling Nlk to act as a key regulator in signaling cascades that are vital for maintaining cellular homeostasis. With specific reactivity and versatile applications, anti-Nlk antibody (H-2) serves as an essential tool for researchers investigating the intricate roles of Nlk in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Nlk Antibody (H-2) References:
- Context-dependent dual and opposite roles of nemo-like kinase in the Wnt/β-catenin signaling. | Ishitani, T. 2012. Cell Cycle. 11: 1743-5. PMID: 22510562
- Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. | Todd, TW., et al. 2015. Elife. 4: e08493. PMID: 26308581
- Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart. | Liu, R., et al. 2016. PLoS One. 11: e0164897. PMID: 27764156
- Expression of Nemo-like kinase in cervical squamous cell carcinoma: a clinicopathological study. | Yang, W., et al. 2018. Onco Targets Ther. 11: 743-749. PMID: 29445289
- Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1. | Li, SZ., et al. 2018. Cancer Lett. 431: 43-53. PMID: 29803790
- Knockdown of Nemo‑like kinase promotes metastasis in non‑small‑cell lung cancer. | Shi, C., et al. 2019. Oncol Rep. 42: 1090-1100. PMID: 31322229
- Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease. | Jiang, M., et al. 2020. Hum Mol Genet. 29: 1340-1352. PMID: 32242231
- Therapeutic Targeting of Nemo-like Kinase in Primary and Acquired Endocrine-resistant Breast Cancer. | Wang, X., et al. 2021. Clin Cancer Res. 27: 2648-2662. PMID: 33542078
- A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis. | Ji, YX., et al. 2021. Cell Metab. 33: 1171-1186.e9. PMID: 33951476
- Nemo-like kinase (NLK) gene regulates apoptosis via the p53 signaling pathway in Litopenaeus vannamei under low-temperature stress. | Yin, X., et al. 2022. Dev Comp Immunol. 131: 104378. PMID: 35231467
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nlk Antibody (H-2) | sc-271323 | 200 µg/ml | $322.00 | |||
Nlk Antibody (H-2): m-IgGκ BP-HRP Bundle | sc-534927 | 200 µg Ab; 40 µg BP | $361.00 | |||
Nlk Antibody (H-2): m-IgG2b BP-HRP Bundle | sc-549317 | 200 µg Ab; 10 µg BP | $361.00 | |||
Nlk (H-2) Neutralizing Peptide | sc-271323 P | 100 µg/0.5 ml | $69.00 |