NKHC2 Antibody (B-9): sc-374469

NKHC2 Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects neuronal kinesin heavy chain 2 (NKHC2) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NKHC2 is a 1,032 amino acid protein belonging to the kinesin superfamily, specifically representing the heavy chains of conventional kinesin, and is predominantly expressed in the central nervous system, with particularly high levels in certain neuronal subsets. The unique C-terminal region of NKHC2, which consists of 69 amino acids, is crucial for its interaction with dystrobrevin, an important adaptor and scaffolding protein. This interaction may facilitate the transport and precise localization of components of the dystrophin-associated protein complex, which is essential for maintaining the structural integrity of muscle cells and neurons. Furthermore, NKHC2 plays a vital role in the microtubule-dependent slow axonal transport of neurofilament proteins, a process that is critical for the maturation and functionality of neuronal cells. Anti-NKHC2 antibody (B-9) is an invaluable tool for researchers studying neuronal transport mechanisms and the pathophysiology of neurodegenerative diseases.

The preferred NKHC2 antibody is NKHC2 Antibody (E-5): sc-374468.