NKG2-A Antibody (16A11): sc-53025

NKG2-A Antibody (16A11) is a mouse monoclonal IgG2b kappa light chain antibody that detects NKG2-A protein of mouse origin by flow cytometry (FCM). anti-NKG2-A antibody (16A11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. NKG2-A plays a crucial role in the regulation of natural killer (NK) cell activity, functioning as an inhibitory receptor that interacts with class I major histocompatibility complex (MHC) molecules. This interaction is vital for maintaining immune homeostasis, as NKG2-A helps prevent NK cell activation against healthy cells, thereby reducing autoimmunity risk. NKG2-A receptor belongs to a larger family of receptors, including the killer cell inhibitory receptor/leukocyte immunoglobulin-like receptor (KIR/LIR) family and C-type lectin superfamily, which collectively modulate NK cell responses. Understanding NKG2-A function is essential for developing therapeutic strategies aimed at enhancing NK cell activity in cancer immunotherapy, where distinguishing between healthy and malignant cells is critical for effective treatment outcomes.

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NKG2-A Antibody (16A11) References:

1. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.  |  Bauer, S., et al. 1999. Science. 285: 727-9. PMID: 10426993
2. Inhibitory role of murine Ly49 lectin-like receptors on natural killer cells.  |  Salcedo, M. 1999. Curr Top Microbiol Immunol. 244: 97-105. PMID: 10453652
3. Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors.  |  Hayami, K., et al. 1997. J Biol Chem. 272: 7320-7. PMID: 9054430
4. Divergent functions of lectin-like receptors on NK cells.  |  Ryan, JC. and Seaman, WE. 1997. Immunol Rev. 155: 79-89. PMID: 9059884
5. Natural killer cell receptors.  |  Long, EO. and Wagtmann, N. 1997. Curr Opin Immunol. 9: 344-50. PMID: 9203417
6. HLA class I specific inhibitory receptors.  |  Moretta, A. and Moretta, L. 1997. Curr Opin Immunol. 9: 694-701. PMID: 9368779
7. Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells.  |  Vance, RE., et al. 1997. Eur J Immunol. 27: 3236-41. PMID: 9464811
8. The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate.  |  Berg, KL., et al. 1998. Oncogene. 17: 2535-41. PMID: 9824165

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NKG2-A Antibody (16A11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-NKG2-A Antibody (16A11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NKG2-A Antibody (16A11) Specifications

Alternate Product Name: NKG2-A

Product Clone Name: 16A11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: NKG2-A

Epitope Species: mouse

Product Reactivity/Detection: NKG2-A

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: FCM

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for NKG2-A Antibody (16A11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin