NK 2B4 Antibody (2B4.69): sc-80900

NK 2B4 Antibody (2B4.69) is a mouse monoclonal IgG1 antibody that detects NK 2B4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). NK 2B4, also known as CD244, is a critical cell surface glycoprotein belonging to the immunoglobulin superfamily, playing a vital role in the regulation of natural killer (NK) and T lymphocyte functions. NK 2B4 is predominantly expressed on all human NK cells and a subset of T cells that exhibit NK-like cytotoxicity, facilitating the recognition and elimination of tumor cells and virally infected cells. NK 2B4′s importance lies in its interaction with CD48, a ligand that enhances NK cell activation and cytotoxicity, thereby contributing to the immune response against malignancies and infections. Additionally, NK 2B4 associates with signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) and Src homology 2 domain-containing protein (SH2D1A), which are crucial for modulating NK 2B4-mediated signaling pathways. NK 2B4′s expression in various human tissues, including the spleen, peripheral blood leukocytes, lymph nodes, bone marrow, and fetal liver, underscores its significance in immune surveillance and response, making anti-NK 2B4 antibody (2B4.69) an essential tool for researchers studying immune cell interactions and functions.

The preferred NK 2B4 antibody is NK 2B4 Antibody (HD2): sc-53596.