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NGFR p75 Antibody (MC-192): sc-53631

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Datasheets
  • NGFR p75 Antibody (MC-192) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
  • raised against PC-12 cells of rat origin
  • recommended for detection of NGFR p75 of mouse and rat origin by WB, IP, IF and FCM
  • available conjugated to either phycoerythrin (sc-53631 PE), FITC (sc-53631 FITC) or Alexa Fluor® 647 (sc-53631 AF647), 200 µg/ml, for IF, IHC(P) and FCM
  • See NGFR p75 (B-1): sc-271708 for NGFR p75 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NGFR p75 Antibody (MC-192) for WB applications. These reagents are now offered in bundles with NGFR p75 Antibody (MC-192) (see ordering information below).
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NGFR p75 Antibody (MC-192) is a mouse monoclonal IgG1 antibody that detects NGFR p75 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). NGFR p75, also known as the p75 neurotrophin receptor, plays a crucial role in the nervous system by modulating the effects of neurotrophic factors, including nerve growth factor (NGF). NGFR p75 is primarily located on the surface of neurons and is essential for neuronal survival, differentiation, and apoptosis. The interaction between NGFR p75 and neurotrophic factors is characterized by low-affinity binding, which allows for the fine-tuning of neuronal responses to these growth factors. NGFR p75 enhances the signaling of the high-affinity Trk receptors, such as Trk A, by accelerating their activation and facilitating the recruitment of downstream signaling molecules. This cooperative interaction is vital for the proper functioning of neuronal circuits and has implications in neurodegenerative diseases and injury responses, making NGFR p75 a key player in neurobiology. Anti-NGFR p75 antibody (MC-192) is an invaluable tool for researchers studying these complex signaling pathways and their effects on neuronal health and disease.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

NGFR p75 Antibody (MC-192)

sc-53631
200 µg/ml
$322.00

NGFR p75 Antibody (MC-192): m-IgG Fc BP-HRP Bundle

sc-536995
200 µg Ab; 10 µg BP
$361.00

NGFR p75 Antibody (MC-192): m-IgGκ BP-HRP Bundle

sc-534175
200 µg Ab; 40 µg BP
$361.00

NGFR p75 Antibody (MC-192): m-IgG1 BP-HRP Bundle

sc-544946
200 µg Ab; 20 µg BP
$361.00

NGFR p75 Antibody (MC-192) FITC

sc-53631 FITC
200 µg/ml
$336.00

NGFR p75 Antibody (MC-192) PE

sc-53631 PE
200 µg/ml
$349.00

NGFR p75 Antibody (MC-192) Alexa Fluor® 647

sc-53631 AF647
200 µg/ml
$364.00

which amino acid sequence was the antibody raised for?

Asked by: Cassiano
Thank you for your question. NGFR p75 Antibody (MC-192): sc-53631 was raised against PC-12 cells of rat origin (accession number P07174). No epitope mapping has been performed for this antibody, so the exact epitope sequence is unknown. If you have further questions please feel free to contact our technical service team directly.
Answered by: Technical Support Europe
Date published: 2019-04-05

Can NGFR p75 (MC-192): sc-53631 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: cjMara
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, NGFR p75 (MC-192): sc-53631 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
  • y_2026, m_4, d_23, h_7CST
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Rated 5 out of 5 by from Published using this antibody in our WesternPublished using this antibody in our Western Blot against human cell lines.
Date published: 2015-08-24
Rated 4 out of 5 by from Very large WB band obtained using PCVery large WB band obtained using PC-12 whole cell lysate under non-reducing conditions. -SCBT QC
Date published: 2013-06-05
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NGFR p75 Antibody (MC-192) is rated 4.5 out of 5 by 2.
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