NGFR p75 Antibody (G-5): sc-25283

NGFR p75 Antibody (G-5) is a mouse monoclonal IgG2a antibody that detects NGFR p75 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NGFR p75, also known as the low-affinity nerve growth factor receptor, plays a crucial role in the nervous system by modulating the effects of neurotrophic factors, particularly nerve growth factor (NGF). NGFR p75 is primarily located on the surface of neurons and glial cells, where NGFR p75 acts as a co-receptor alongside Trk A, enhancing the signaling pathways initiated by NGF. The interaction between NGFR p75 and Trk A is essential for efficient signal transduction, as NGFR p75 not only accelerates the activation of Trk A but also facilitates the recruitment of downstream effector molecules, thereby amplifying the neurotrophic response. The importance of NGFR p75 in neuronal survival and differentiation underscores NGFR p75′s potential as a therapeutic target in neurodegenerative diseases and conditions involving neuronal injury. Anti-NGFR p75 antibody (G-5) is an invaluable tool for researchers investigating the intricate signaling mechanisms of neurotrophic factors in human tissues.

The preferred NGFR p75 antibody is NGFR p75 Antibody (ME20.4): sc-13577.