NGFR p75 Antibody (B-1): sc-271708

NGFR p75 Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects NGFR p75 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-NGFR p75 antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NGFR p75 plays a crucial role in the nervous system by modulating the effects of neurotrophic factors, particularly nerve growth factor (NGF). NGFR p75 is primarily located on the surface of neurons and is essential for neuronal survival and differentiation. By binding to neurotrophic factors with low affinity, NGFR p75 enhances the signaling efficiency of the high-affinity Trk receptors, such as Trk A, which are vital for mediating the neuroprotective effects of NGF. This interaction accelerates the activation of Trk A and facilitates the recruitment of downstream signaling molecules, thereby influencing neuronal development and response to injury. NGFR p75′s ability to modulate Trk receptor signaling underscores its importance in neurobiology and potential implications in neurodegenerative diseases and therapeutic strategies.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NGFR p75 Antibody (B-1) has 40 citations in a variety of scientific publications.

Primary antibodies like Anti-NGFR p75 Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NGFR p75 Antibody (B-1) Specifications

Alternate Product Name: NGFR p75

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 393-427

Epitope Target: NGFR p75

Epitope Species: human

Product Reactivity/Detection: NGFR p75

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 40 citations in various scientific publications

Available Conjugates/Forms for NGFR p75 Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred NGFR p75 antibody is NGFR p75 Antibody (ME20.4): sc-13577.