NFKBIL1 Antibody (C-5): sc-518230

NFKBIL1 Antibody (C-5) is a mouse monoclonal IgG1 antibody specific for an epitope mapping between amino acids 220-246 of NFKBIL1 of human origin through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NFKBIL1, also known as IKBL, plays a crucial role as a negative regulator of NFκB activation, which is essential for maintaining the balance of immune responses and preventing excessive inflammation. NFKBIL1 is primarily located in the cytoplasm, where NFKBIL1 associates with NFκB inhibitory proteins and directly interacts with the NFκB complex to inhibit phosphorylation and translocation to the nucleus. This prevents the transcription of pro-inflammatory and immune-activating genes, maintaining cellular homeostasis and immune equilibrium. Cytoplasmic localization of NFKBIL1 ensures accessibility to regulate NFκB signaling promptly, acting as a safeguard against aberrant immune responses. Dysregulation of this pathway is implicated in various autoimmune and inflammatory diseases, such as type 1 diabetes, rheumatoid arthritis, and ulcerative colitis, underscoring NFKBIL1′s importance in health and disease. By utilizing anti-NFKBIL1 antibody (C-5), researchers can explore the molecular mechanisms governing NFκB regulation and its broader implications in disease pathology, making this tool a critical resource for advancing our understanding of inflammation and immune modulation.

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NFKBIL1 Antibody (C-5) References:

1. The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy.  |  Shichi, D., et al. 2005. Tissue Antigens. 66: 200-8. PMID: 16101831
2. Direct determination of single nucleotide polymorphism haplotype of NFKBIL1 promoter polymorphism by DNA conformation analysis and its application to association study of chronic inflammatory diseases.  |  Shibata, H., et al. 2006. Hum Immunol. 67: 363-73. PMID: 16720219
3. Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample.  |  Ryan, AW., et al. 2008. Atherosclerosis. 197: 465-6. PMID: 17485095
4. Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.  |  Koch, W., et al. 2007. Hum Mol Genet. 16: 1821-7. PMID: 17517687
5. Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals.  |  Ramasawmy, R., et al. 2008. Mol Immunol. 45: 283-8. PMID: 17544510
6. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis.  |  Kominami, S., et al. 2009. J Hum Genet. 54: 108-14. PMID: 19165231
7. NFKBIL1 confers resistance to experimental autoimmune arthritis through the regulation of dendritic cell functions.  |  Chiba, T., et al. 2011. Scand J Immunol. 73: 478-85. PMID: 21284685
8. A novel link of HLA locus to the regulation of immunity and infection: NFKBIL1 regulates alternative splicing of human immune-related genes and influenza virus M gene.  |  An, J., et al. 2013. J Autoimmun. 47: 25-33. PMID: 23953137
9. Genetic variation on the BAT1-NFKBIL1-LTA region of major histocompatibility complex class III associates with periodontitis.  |  Kallio, KA., et al. 2014. Infect Immun. 82: 1939-48. PMID: 24566624
10. Associations between autistic-like traits and polymorphisms in NFKBIL1.  |  Strenn, N., et al. 2019. Acta Neuropsychiatr. 31: 220-229. PMID: 31162003

The preferred NFKBIL1 antibody is NFKBIL1 Antibody (A-6): sc-518229.