NFATc2IP Antibody (B-1): sc-377461

NFATc2IP Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects NFATc2IP of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-NFATc2IP antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NFATc2IP, also known as nuclear factor of activated T cells 2 interacting protein or NIP45, is a 419 amino acid protein that plays a crucial role in the immune response by localizing to both the nucleus and cytoplasm, where NFATc2IP contains a ubiquitin-like domain. NFATc2IP is essential for the inducible expression of cytokines in T-cells, as NFATc2IP enhances NFATc2-induced interleukin production, thereby influencing T-cell activation and differentiation. NFATc2IP interacts with key proteins such as NFATc2, TRAF1, and TRAF2, which are vital for signaling pathways that regulate immune responses. Additionally, NFATc2IP exists as three alternatively spliced isoforms and undergoes post-translational methylation, a modification that further enhances NFATc2IP′s ability to regulate cytokine production. The gene encoding NFATc2IP is located on human chromosome 16, a region associated with various genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome, highlighting NFATc2IP′s importance in both normal immune function and disease states.

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NFATc2IP Antibody (B-1) References:

1. Sequential involvement of NFAT and Egr transcription factors in FasL regulation.  |  Rengarajan, J., et al. 2000. Immunity. 12: 293-300. PMID: 10755616
2. Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45).  |  Lieberson, R., et al. 2001. J Exp Med. 194: 89-98. PMID: 11435475
3. Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes.  |  Mowen, KA., et al. 2004. Mol Cell. 15: 559-71. PMID: 15327772
4. Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family.  |  Novatchkova, M., et al. 2005. BMC Bioinformatics. 6: 22. PMID: 15698469
5. TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.  |  Bryce, PJ., et al. 2006. Int Immunol. 18: 101-11. PMID: 16352630
6. Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2).  |  Koch, S., et al. 2019. Sci Rep. 9: 15695. PMID: 31666531
7. Calcium channel TRPV6 promotes breast cancer metastasis by NFATC2IP.  |  Xu, X., et al. 2021. Cancer Lett. 519: 150-160. PMID: 34265397
8. NFATC2IP is a mediator of SUMO-dependent genome integrity.  |  Cho, T., et al. 2024. Genes Dev. 38: 233-252. PMID: 38503515
9. miR-31-5p suppresses myocardial hypertrophy by targeting Nfatc2ip.  |  Zhao, L., et al. 2024. J Cell Mol Med. 28: e18413. PMID: 38894694
10. NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes.  |  Rao, A. 1994. Immunol Today. 15: 274-81. PMID: 8068174
11. The inducible transcription factor NF-AT plays an important role in the activation of the murine interleukin-4 promoter.  |  Schneider, G., et al. 1995. Immunobiology. 193: 268-72. PMID: 8530154
12. NF-AT-Driven interleukin-4 transcription potentiated by NIP45.  |  Hodge, MR., et al. 1996. Science. 274: 1903-5. PMID: 8943202

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NFATc2IP Antibody (B-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-NFATc2IP Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NFATc2IP Antibody (B-1) Specifications

Alternate Product Name: NFATc2IP

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 221-419

Epitope Target: NFATc2IP

Epitope Species: human

Product Reactivity/Detection: NFATc2IP of human origin, NIP45 of mouse origin and the corresponding rat homolog

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for NFATc2IP Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent