NFATc2 Antibody (G1-D10): sc-7295
- NFATc2 Antibody (G1-D10) is a mouse monoclonal IgG2a κ, cited in 44 publications, provided at 200 µg/ml
- raised against amino acids 433-567 of NFATc2 of mouse origin
- recommended for detection of NFATc2 of mouse, rat and human origin by IP and IF; not recommended for WB
- TransCruz reagent for Gel Supershift and ChIP applications (sc-7295 X, 200 µg/0.1 ml)
- See NFATc2 (4G6-G5): sc-7296 for NFATc2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NFATc2 Antibody (G1-D10). These reagents are now offered in bundles with NFATc2 Antibody (G1-D10) (see ordering information below).
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NFATc2 Antibody (G1-D10) is a mouse monoclonal IgG2a antibody that detects NFATc2 in mouse, rat, and human samples through immunoprecipitation (IP) and immunofluorescence (IF) applications. NFATc2 plays a crucial role in the regulation of cytokine gene expression in T cells, which is vital for the immune response. Upon recognition of an antigen by the T cell receptor, the calcium-dependent protein phosphatase calcineurin is activated, leading to the translocation of NFATc2 from the cytoplasm to the nucleus. In the nucleus, NFATc2 collaborates with AP-1 transcription factors to initiate the transcription of cytokine genes, thereby influencing T cell activation and differentiation. This process is essential for the proper functioning of the immune system, as NFATc2 ensures that T cells can effectively respond to pathogens. The ability of NFATc2 to synergize with other transcription factors highlights its importance in the complex network of immune signaling pathways, making NFATc2 (G1-D10) monoclonal antibody an invaluable tool for studying these critical processes in various experimental settings.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NFATc2 Antibody (G1-D10) References:
- NFATc2 is an intrinsic regulator of melanoma dedifferentiation. | Perotti, V., et al. 2016. Oncogene. 35: 2862-72. PMID: 26387540
- Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer. | Zhu, L., et al. 2022. Nat Cell Biol. 24: 1165-1176. PMID: 35773432
- Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation. | Nagai, J., et al. 2022. J Immunol. 209: 2293-2303. PMID: 36307120
- Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection. | Brewer, WJ., et al. 2022. Cell Rep. 41: 111817. PMID: 36516756
- NFATC1 and NFATC2 expression patterns in human osteochondromas. | Wang, Y., et al. 2023. Heliyon. 9: e13018. PMID: 36747924
- Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma. | Zhao, W., et al. 2023. Lab Invest. 103: 100193. PMID: 37285922
- RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/β-catenin signaling pathway through degrading TRIM14. | Lv, R., et al. 2023. Int Immunopharmacol. 125: 111191. PMID: 37951197
- NFATc2 promotes lactate and M2 macrophage polarization through USP17 in lung adenocarcinoma. | Wang, L., et al. 2024. Anticancer Drugs. 35: 385-396. PMID: 38386130
- The Dual Role of the NFATc2/galectin-9 Axis in Modulating Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma. | Xiao, ZJ., et al. 2024. Adv Sci (Weinh). 11: e2306059. PMID: 38528665
- AS101 regulates the Teff/Treg balance to alleviate rabbit autoimmune dacryoadenitis through modulating NFATc2. | Wang, X., et al. 2024. Exp Eye Res. 244: 109937. PMID: 38782179
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NFATc2 Antibody (G1-D10) | sc-7295 | 200 µg/ml | $316.00 | |||
NFATc2 Antibody (G1-D10): m-IgG Fc BP-HRP Bundle | sc-536551 | 200 µg Ab; 10 µg BP | $354.00 | |||
NFATc2 Antibody (G1-D10): m-IgGκ BP-HRP Bundle | sc-533702 | 200 µg Ab; 40 µg BP | $354.00 | |||
NFATc2 Antibody (G1-D10): m-IgG2a BP-HRP Bundle | sc-547836 | 200 µg Ab; 10 µg BP | $354.00 | |||
NFATc2 Antibody (G1-D10) X | sc-7295 X | 200 µg/0.1 ml | $316.00 |