NF90 Antibody (21): sc-136197
- NF90 Antibody (21) is a mouse monoclonal IgG1, cited in 4 publications, provided at 50 µg/0.5 ml
- raised against amino acids 592-695 of NF90 of human origin
- recommended for detection of NF90 of human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NF90 Antibody (21). This work is in progress.
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NF90 Antibody (21) is a mouse monoclonal IgG1 antibody that detects NF90 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). NF90, also known as nuclear factor of activated T-cells 90 kDa, plays a crucial role in the regulation of gene expression, particularly in the immune response, by binding to double-stranded RNA and modulating the activity of various signaling pathways. NF90 is predominantly located in the nucleus, where NF90 forms a heterodimer with NF45, and is essential for the regulation of interleukin-2 expression, a key cytokine in T-cell activation and proliferation. The interaction between NF90 and NF45 not only influences immune responses but also has implications in viral infections, as this complex can inhibit the replication of certain viruses by binding to their RNA. Additionally, NF90 undergoes alternative splicing, resulting in multiple isoforms that may have distinct functions, further underscoring the complexity and importance of NF90 in cellular processes. Anti-NF90 antibody (21) is an invaluable tool for researchers studying immune regulation, viral pathogenesis, and the intricate mechanisms of RNA-binding proteins.
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NF90 Antibody (21) References:
- NF90 in posttranscriptional gene regulation and microRNA biogenesis. | Masuda, K., et al. 2013. Int J Mol Sci. 14: 17111-21. PMID: 23965975
- NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells. | Wen, X., et al. 2014. J Immunol. 192: 3753-64. PMID: 24623135
- The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology. | Wandrey, F., et al. 2015. Mol Cell Biol. 35: 3491-503. PMID: 26240280
- NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma. | Song, D., et al. 2017. Biochem Biophys Res Commun. 488: 211-217. PMID: 28487110
- NF90 regulation of immune factor expression in response to malaria antigens. | Idda, ML., et al. 2019. Cell Cycle. 18: 708-722. PMID: 30784348
- NF90 modulates processing of a subset of human pri-miRNAs. | Grasso, G., et al. 2020. Nucleic Acids Res. 48: 6874-6888. PMID: 32427329
- NF45/NF90-mediated rDNA transcription provides a novel target for immunosuppressant development. | Tsai, HI., et al. 2021. EMBO Mol Med. 13: e12834. PMID: 33555115
- NF90 interacts with components of RISC and modulates association of Ago2 with mRNA. | Grasso, G., et al. 2022. BMC Biol. 20: 194. PMID: 36050755
- The Polyvalent Role of NF90 in RNA Biology. | Grasso, G. and Kiernan, R. 2022. Int J Mol Sci. 23: PMID: 36362366
- Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis. | Xie, F., et al. 2024. Nat Commun. 15: 4985. PMID: 38862515
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NF90 Antibody (21) | sc-136197 | 50 µg/0.5 ml | $322.00 |