NF-M Antibody (2Q168): sc-71688
- NF-M Antibody (2Q168) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µl ascites
- raised against the C-terminus of recombinant NF-M of rat origin
- recommended for detection of NF-M of mouse, rat and human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NF-M Antibody (2Q168). This work is in progress.
NF-M Antibody (2Q168) is a mouse monoclonal IgG1 antibody that detects Neurofilament-M (NF-M) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-NF-M antibody (2Q168) is available in non-conjugated form. Neurofilament-M is a crucial component of the neuronal cytoskeleton, belonging to the intermediate filament family, and plays a significant role in maintaining the structural integrity of neurons. NF-M (2Q168) antibody targets a protein that provides mechanical support to axons, essential for proper neuronal function and communication. Neurofilament-M undergoes various post-translational modifications, including phosphorylation, which can influence stability and interactions with other cytoskeletal elements. These modifications affect the dynamics of neurofilament assembly and disassembly, ultimately impacting neuronal health. Dysregulation of NF-M phosphorylation has been implicated in several neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), Parkinson′s disease, and Alzheimer′s disease, highlighting NF-M′s importance in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NF-M Antibody (2Q168) References:
- Neurofilament-M interacts with the D1 dopamine receptor to regulate cell surface expression and desensitization. | Kim, OJ., et al. 2002. J Neurosci. 22: 5920-30. PMID: 12122054
- Mutation analysis of the neurofilament M gene in Parkinson's disease. | Krüger, R., et al. 2003. Neurosci Lett. 351: 125-9. PMID: 14583397
- NF-M is an essential target for the myelin-directed 'outside-in' signaling cascade that mediates radial axonal growth. | Garcia, ML., et al. 2003. J Cell Biol. 163: 1011-20. PMID: 14662745
- A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. | Harris, J., et al. 1991. J Neurosci Res. 30: 47-62. PMID: 1724473
- Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease. | Deng, Y., et al. 2008. FASEB J. 22: 138-45. PMID: 17687114
- How the projection domains of NF-L and alpha-internexin determine the conformations of NF-M and NF-H in neurofilaments. | Leermakers, FA. and Zhulina, EB. 2010. Eur Biophys J. 39: 1323-34. PMID: 20213320
- Hypophosphorylation of NF-H and NF-M subunits of neurofilaments and the associated decrease in KSPXK kinase activity in the sciatic nerves of swiss white mice inoculated in the foot pad with mycobacterium leprae. | Save, MP., et al. 2009. Lepr Rev. 80: 388-401. PMID: 20306637
- Expression of rat neurofilament proteins NF-L and NF-M in transfected non-neuronal cells. | Chin, SS. and Liem, RK. 1989. Eur J Cell Biol. 50: 475-90. PMID: 2516804
- cAMP-dependent phosphorylation of neurofilament proteins NF-L and NF-M inhibits their coassembly into filaments in vitro. | Streifel, TD., et al. 1996. Biochem Biophys Res Commun. 222: 646-51. PMID: 8670258
- Assembly properties of amino- and carboxyl-terminally truncated neurofilament NF-H proteins with NF-L and NF-M in the presence and absence of vimentin. | Sun, D., et al. 1997. J Neurochem. 68: 917-26. PMID: 9048736
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NF-M Antibody (2Q168) | sc-71688 | 50 µl ascites | $316.00 |