NF-1 Antibody (A-12): sc-74445
- NF-1 Antibody (A-12) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1-300 of NF-1 of human origin
- recommended for detection of all NF-1 isoforms of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications (sc-74445 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for NF-1 Antibody (A-12) for WB and IHC(P) applications. These reagents are now offered in bundles with NF-1 Antibody (A-12) (see ordering information below).
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NF-1 Antibody (A-12) is a mouse monoclonal IgG1 antibody that detects NF-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NF-1, also known as CTF, is a crucial member of the CCAAT box binding protein family, playing a significant role in stimulating DNA replication and activating transcription. NF-1 binds to specific DNA elements as a homodimer, utilizing an amino-terminal DNA binding domain, and activates transcription through a unique proline-rich carboxy-terminal transactivation domain. NF-1 has been shown to interact with the adenovirus type 2 promoter and is involved in the transcriptional activation of herpes simplex virus thymidine kinase genes. The consensus element recognized by NF-1 is present in the upstream promoter regions of numerous eukaryotic genes, including those for Ha-Ras, α-globin, HSP 70, GRP 78, Histone H1, and myelin basic protein, as well as in the promoter of the Xenopus laevis vitellogenin gene. Anti-NF-1 antibody (A-12) versatility in various applications makes this reagent an essential tool for researchers studying gene regulation and protein interactions in diverse biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NF-1 Antibody (A-12) References:
- Ras/Raf/ERK signalling and NF1. | Harrisingh, MC. and Lloyd, AC. 2004. Cell Cycle. 3: 1255-8. PMID: 15467460
- Neurofibromatosis type 1 (NF1) and associated tumors. | Rosenbaum, T. and Wimmer, K. 2014. Klin Padiatr. 226: 309-15. PMID: 25062113
- The NF1 gene in tumor syndromes and melanoma. | Kiuru, M. and Busam, KJ. 2017. Lab Invest. 97: 146-157. PMID: 28067895
- Human stem cell modeling in neurofibromatosis type 1 (NF1). | Wegscheid, ML., et al. 2018. Exp Neurol. 299: 270-280. PMID: 28392281
- Hereditary Diseases Predisposing to Pheochromocytoma (VHL, NF-1, Paraganglioma Syndromes, and Novel Genes). | Sarkadi, B. and Patócs, A. 2019. Exp Suppl. 111: 129-147. PMID: 31588531
- Non-Oncological Neuroradiological Manifestations in NF1 and Their Clinical Implications. | Russo, C., et al. 2021. Cancers (Basel). 13: PMID: 33921292
- NF1 alterations in cancers: therapeutic implications in precision medicine. | Giraud, JS., et al. 2023. Expert Opin Investig Drugs. 32: 941-957. PMID: 37747491
- The efficacy of statins for improving cognitive impairments in pediatric patients with neurofibromatosis type 1 (NF-1): a meta-analysis. | Gan, L., et al. 2023. Front Pediatr. 11: 1274972. PMID: 37876519
- Impact of trametinib on the neuropsychological profile of NF1 patients. | Lalancette, E., et al. 2024. J Neurooncol. 167: 447-454. PMID: 38443693
- Past, Present, and Future Therapeutic Strategies for NF-1-Associated Tumors. | Na, B., et al. 2024. Curr Oncol Rep. 26: 706-713. PMID: 38709422
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NF-1 Antibody (A-12) | sc-74445 | 200 µg/ml | $322.00 | |||
NF-1 Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-539520 | 200 µg Ab; 10 µg BP | $361.00 | |||
NF-1 Antibody (A-12): m-IgG1 BP-HRP Bundle | sc-541541 | 200 µg Ab; 20 µg BP | $361.00 | |||
NF-1 Antibody (A-12) X | sc-74445 X | 200 µg/0.1 ml | $322.00 |