neuroserpin Antibody (C-9): sc-48360
- neuroserpin Antibody (C-9) is a mouse monoclonal IgG1 κ neuroserpin antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 61-150 mapping within an internal region of neuroserpin of human origin
- neuroserpin Antibody (C-9) is recommended for detection of neuroserpin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-neuroserpin Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for neuroserpin Antibody (C-9) for WB applications. These reagents are now offered in bundles with neuroserpin Antibody (C-9) (see ordering information below).
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neuroserpin Antibody (C-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects neuroserpin of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-neuroserpin antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neuroserpin is a crucial axonally secreted glycoprotein in the central nervous system (CNS) that belongs to the serpin family of protease inhibitors. Neuroserpin plays a significant role as a serine-protease inhibitor, forming stable complexes with tissue plasminogen activator (tPA), urokinase, and plasmin, while not interacting with thrombin. Neuroserpin expression is localized in key areas of the adult CNS, including the neocortex, hippocampal formation, olfactory bulb, and amygdala, as well as in the developing cerebellum, granule cells, and a subset of Purkinje cells. Neuroserpin interaction with tPA is particularly important, as tPA is associated with neuronal plasticity, which is vital for processes such as synaptic remodeling and long-term potentiation. Excessive tPA expression can lead to neuronal cell death, highlighting the delicate balance maintained by neuroserpin in neuroprotection. Mutations in the gene encoding neuroserpin have been linked to hereditary dementia, underscoring neuroserpin significance in neurodegenerative diseases. Intracerebral administration of neuroserpin following a stroke has been shown to reduce stroke volume and mitigate apoptotic features in the ischemic penumbra, demonstrating neuroserpin potential therapeutic applications in neuroprotection and recovery.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
neuroserpin Antibody (C-9) References:
- Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis. | Yepes, M., et al. 2000. Blood. 96: 569-76. PMID: 10887120
- Biochemical characterization of a neuroserpin variant associated with hereditary dementia. | Yazaki, M., et al. 2001. Am J Pathol. 158: 227-33. PMID: 11141496
- The serpins: nature's molecular mousetraps. | Huntington, JA. and Carrell, RW. 2001. Sci Prog. 84: 125-36. PMID: 11525014
- Neuroserpin, an axonally secreted serine protease inhibitor. | Osterwalder, T., et al. 1996. EMBO J. 15: 2944-53. PMID: 8670795
- Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. | Krueger, SR., et al. 1997. J Neurosci. 17: 8984-96. PMID: 9364046
- Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival. | Hastings, GA., et al. 1997. J Biol Chem. 272: 33062-7. PMID: 9407089
- The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin. | Osterwalder, T., et al. 1998. J Biol Chem. 273: 2312-21. PMID: 9442076
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
neuroserpin Antibody (C-9) | sc-48360 | 200 µg/ml | $316.00 | |||
neuroserpin Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-528529 | 200 µg Ab; 10 µg BP | $354.00 | |||
neuroserpin Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-520925 | 200 µg Ab, 40 µg BP | $354.00 | |||
neuroserpin Antibody (C-9): m-IgG1 BP-HRP Bundle | sc-542978 | 200 µg Ab; 20 µg BP | $354.00 | |||
neuroserpin Antibody (C-9) AC | sc-48360 AC | 500 µg/ml, 25% agarose | $416.00 | |||
neuroserpin Antibody (C-9) HRP | sc-48360 HRP | 200 µg/ml | $316.00 | |||
neuroserpin Antibody (C-9) FITC | sc-48360 FITC | 200 µg/ml | $330.00 | |||
neuroserpin Antibody (C-9) PE | sc-48360 PE | 200 µg/ml | $343.00 | |||
neuroserpin Antibody (C-9) Alexa Fluor® 488 | sc-48360 AF488 | 200 µg/ml | $357.00 | |||
neuroserpin Antibody (C-9) Alexa Fluor® 546 | sc-48360 AF546 | 200 µg/ml | $357.00 | |||
neuroserpin Antibody (C-9) Alexa Fluor® 594 | sc-48360 AF594 | 200 µg/ml | $357.00 | |||
neuroserpin Antibody (C-9) Alexa Fluor® 647 | sc-48360 AF647 | 200 µg/ml | $357.00 | |||
neuroserpin Antibody (C-9) Alexa Fluor® 680 | sc-48360 AF680 | 200 µg/ml | $357.00 | |||
neuroserpin Antibody (C-9) Alexa Fluor® 790 | sc-48360 AF790 | 200 µg/ml | $357.00 |