neurolysin Antibody (C-4): sc-398613

Neurolysin Antibody (C-4) is a mouse monoclonal IgG2a antibody that detects neurolysin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Neurolysin is a zinc-dependent metallopeptidase that plays a crucial role in the regulation of neuropeptides, which are essential for neurotransmission and neurohormonal signaling. By selectively cleaving short peptides, neurolysin modulates the activity of various neuropeptides, thereby influencing numerous physiological processes, including pain perception, stress response, and circadian rhythms. The unique structure of neurolysin, characterized by extended connecting loop regions within its five-stranded beta-sheet and two active site helices, allows neurolysin to accommodate a diverse range of peptide substrates, enhancing functional versatility. This structural adaptability is vital for neurolysin′s role in the central nervous system, where precise modulation of neuropeptide activity is necessary for maintaining homeostasis and responding to environmental changes. Neurolysin is ubiquitously expressed in the brain and is specifically localized to neuronal perikarya, underscoring neurolysin′s importance in neuronal function and signaling pathways. Anti-neurolysin antibody (C-4) is an invaluable tool for researchers investigating the intricate roles of neuropeptides in health and disease.

The preferred neurolysin antibody is neurolysin Antibody (B-3): sc-398420.