Neuregulin-1/NRG1 Antibody (E-12): sc-393006

Neuregulin-1 Antibody (E-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects Neuregulin-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Neuregulin-1 antibody (E-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neuregulin-1 plays a crucial role in cell signaling, particularly in the development and function of the nervous system, where Neuregulin-1 is involved in regulating cell migration, differentiation of neural crest and Schwann cells, and upregulation of acetylcholine receptors at muscle fibers during neuromuscular junction formation. NRG1 gene produces multiple splice variants, each with unique structural features and functions, contributing to diverse roles in neural development and synaptic plasticity. Neuregulin-1 has been implicated in various neurological disorders, including schizophrenia, highlighting Neuregulin-1′s importance in both normal physiology and disease states. Multiple isoforms of Neuregulin-1, characterized by EGF-like domains and varying glycosylation patterns, underscore the complexity of regulatory mechanisms and interactions within the cellular environment.

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Neuregulin-1/NRG1 Antibody (E-12) References:

1. Receptor binding and biological activity of mammalian expressed sensory and motor neuron-derived factor (SMDF).  |  Osheroff, PL., et al. 1999. Growth Factors. 16: 241-53. PMID: 10372964
2. Identification of heregulin, a specific activator of p185erbB2.  |  Holmes, WE., et al. 1992. Science. 256: 1205-10. PMID: 1350381
3. Multiple novel transcription initiation sites for NRG1.  |  Steinthorsdottir, V., et al. 2004. Gene. 342: 97-105. PMID: 15527969
4. Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia.  |  Li, D., et al. 2006. Hum Mol Genet. 15: 1995-2002. PMID: 16687441
5. Neuregulin-1/ErbB signaling and chronic heart failure.  |  Xu, Y., et al. 2010. Adv Pharmacol. 59: 31-51. PMID: 20933198
6. Neuregulin-1 and schizophrenia in the genome-wide association study era.  |  Mostaid, MS., et al. 2016. Neurosci Biobehav Rev. 68: 387-409. PMID: 27283360
7. Neuregulin-1 attenuates stress-induced vascular senescence.  |  Shakeri, H., et al. 2018. Cardiovasc Res. 114: 1041-1051. PMID: 29528383
8. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.  |  Coussens, L., et al. 1985. Science. 230: 1132-9. PMID: 2999974
9. Neuregulin-1 attenuates hemolysis- and ischemia induced-cerebrovascular inflammation associated with sickle cell disease.  |  Chambliss, C., et al. 2023. J Stroke Cerebrovasc Dis. 32: 106912. PMID: 36473396
10. Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.  |  Marchionni, MA., et al. 1993. Nature. 362: 312-8. PMID: 8096067
11. Isoform-specific expression and function of neuregulin.  |  Meyer, D., et al. 1997. Development. 124: 3575-86. PMID: 9342050
12. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system.  |  Britsch, S., et al. 1998. Genes Dev. 12: 1825-36. PMID: 9637684

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Neuregulin-1/NRG1 Antibody (E-12) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-Neuregulin-1/NRG1 Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Neuregulin-1/NRG1 Antibody (E-12) Specifications

Alternate Product Name: NRG1

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 21-230

Epitope Target: Neuregulin-1 isoform HRG-α

Epitope Species: human

Product Reactivity/Detection: Neuregulin-1 isoforms HRG-α, HRG-α1A, HRG-α2B, HRG-α3, HRG-β1, HRG-β2, HRG-β3 (GGF), GGF2 and SMDF

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for Neuregulin-1/NRG1 Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin