netrin-1 Antibody (5H8): sc-293197
- netrin-1 Antibody (5H8) is a mouse monoclonal IgG2a κ netrin-1 antibody, cited in 2 publications, provided at 100 µg/ml
- raised against a partial recombinant protein mapping to amino acids 495-604 of netrin-1 of human origin
- recommended for detection of netrin-1 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for netrin-1 Antibody (5H8). This work is in progress.
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netrin-1 Antibody (5H8) is a mouse monoclonal IgG2a kappa light chain antibody that detects netrin-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). netrin-1 Antibody (5H8) is available as a non-conjugated anti-netrin-1 antibody. Netrin-1 is a crucial member of the netrin family, which consists of laminin-related secreted proteins that play a vital role in guiding axonal growth and cell migration during embryonic development. Netrin-1 is predominantly expressed in the developing nervous system and mesodermal tissues, where netrin-1 is secreted by the floor plate in both a cell-associated form and as a diffusible molecule. Netrin-1 interacts with several receptors, including deleted in colorectal cancer (DCC) and neogenin, to form a chemoattractant gradient that directs axonal migration towards the ventral midline of the spinal cord. Netrin-1′s role in neuronal pathfinding is essential for proper nervous system development. Additionally, netrin-1′s signaling is modulated by extracellular calcium levels and protein kinase A (PKA) activity, highlighting complex regulatory mechanisms. A decrease in PKA activity can switch the response of axonal cells from attraction to repulsion, demonstrating the dynamic nature of netrin signaling in guiding neuronal connections.
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netrin-1 Antibody (5H8) References:
- Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice. | Ni, S., et al. 2019. Nat Commun. 10: 5643. PMID: 31822662
- Macrophage-derived netrin-1 drives adrenergic nerve-associated lung fibrosis. | Gao, R., et al. 2021. J Clin Invest. 131: PMID: 33393489
- Netrin-1 promotes retinoblastoma-associated angiogenesis. | Yang, X., et al. 2021. Ann Transl Med. 9: 1683. PMID: 34988192
- Netrin-1: An emerging player in inflammatory diseases. | Xia, X., et al. 2022. Cytokine Growth Factor Rev. 64: 46-56. PMID: 35082104
- Netrin-1 mediates nerve innervation and angiogenesis leading to discogenic pain. | Zheng, B., et al. 2023. J Orthop Translat. 39: 21-33. PMID: 36605621
- Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis. | Lu, X., et al. 2023. Biomater Res. 27: 3. PMID: 36647161
- Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis. | Li, Y., et al. 2023. Theranostics. 13: 2319-2336. PMID: 37153740
- Pharmacological targeting of netrin-1 inhibits EMT in cancer. | Lengrand, J., et al. 2023. Nature. 620: 402-408. PMID: 37532929
- Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer. | Cassier, PA., et al. 2023. Nature. 620: 409-416. PMID: 37532934
- Netrin-1 signaling pathway mechanisms in neurodegenerative diseases. | Zhu, K., et al. 2025. Neural Regen Res. 20: 960-972. PMID: 38989931
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
netrin-1 Antibody (5H8) | sc-293197 | 100 µg/ml | $322.00 |