netrin-1 Inhibitors
The class of netrin-1 inhibitors stands as a diverse and sophisticated array of chemical compounds strategically designed to meticulously modulate netrin-1 signaling, providing valuable insights into the intricate regulatory networks governing various physiological contexts. Both direct and indirect inhibitors contribute to unraveling the multifaceted roles of netrin-1 in cellular processes. Among the direct inhibitors, RepSox disrupts netrin-1 signaling by inhibiting the TGF-β pathway. This direct modulation with RepSox offers researchers a pharmacological tool to investigate the complex crosstalk between netrin-1 and the TGF-β pathway, elucidating the molecular interplay between these two signaling cascades. Another direct inhibitor, ML141, targets Rac1, providing a valuable tool to decipher the molecular mechanisms underpinning netrin-1-mediated cellular processes, particularly in cytoskeletal dynamics and migration.
On the indirect front, SB 431542 and LY364947 modulate netrin-1 activity by impacting the TGF-β pathway. These indirect inhibitors selectively target TGF-β type I receptors, influencing downstream cascades and shedding light on the intricate crosstalk between TGF-β and netrin-1. Y-27632 and H-1152, inhibitors of ROCK, exert their effects indirectly by impacting netrin-1 signaling crucial for cytoskeletal dynamics and cellular motility. Moreover, selective inhibition of Rac1 by compounds like NSC23766 and EHT 1864, as well as ROCK inhibition by GSK 269962A, introduces additional layers of control over netrin-1 signaling. These indirect inhibitors provide valuable tools for studying netrin-1-mediated processes, particularly in the context of neuronal development and cellular migration. The selective actions of these chemicals, each with a specific mode of action, significantly contribute to advancing our understanding of the molecular intricacies underlying netrin-1 functions in health and disease. In conclusion, the netrin-1 inhibitor class serves as a sophisticated toolbox for researchers, offering both direct and indirect avenues to explore and manipulate netrin-1 signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $77.00 $153.00 $219.00 $663.00 $1248.00 $4382.00 $7850.00 | 8 | |
RepSox is a direct inhibitor of netrin-1, disrupting its signaling by inhibiting the TGF-β pathway. Acting as a selective TGF-β receptor inhibitor, RepSox modulates netrin-1-mediated cellular processes by interfering with downstream signaling cascades. This small molecule provides a pharmacological tool for investigating the intricate crosstalk between TGF-β and netrin-1 pathways, shedding light on their roles in developmental and pathological processes. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a direct inhibitor of netrin-1 through the inhibition of the small GTPase Rac1. By selectively targeting Rac1, ML141 disrupts netrin-1-mediated cellular processes, influencing cytoskeletal dynamics and migration. This compound offers precise control over netrin-1 activity, unraveling its involvement in axon guidance and cellular motility. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB 431542 is an indirect inhibitor of netrin-1 through the modulation of the TGF-β pathway. As a selective inhibitor of TGF-β type I receptors, SB 431542 impacts netrin-1 signaling by altering downstream TGF-β cascades. This indirect inhibition influences netrin-1-mediated cellular processes, providing insights into the regulatory networks connecting TGF-β and netrin-1 pathways. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
LY364947 is an indirect inhibitor of netrin-1 through the modulation of the TGF-β pathway. Acting as a selective TGF-β receptor inhibitor, LY364947 alters downstream TGF-β cascades, impacting netrin-1-mediated cellular processes. This indirect inhibition provides insights into the intricate crosstalk between TGF-β and netrin-1 pathways, contributing to our understanding of netrin-1's roles in developmental processes and pathological conditions. | ||||||
TGF-β RI Kinase Inhibitor VIII | 356559-20-1 | sc-203295 | 2 mg | $100.00 | 2 | |
SB 525334 is an indirect inhibitor of netrin-1 through the modulation of the TGF-β pathway. As a selective inhibitor of TGF-β type I receptors, SB 525334 impacts netrin-1 signaling by altering downstream TGF-β cascades. This indirect inhibition influences netrin-1-mediated cellular processes, providing insights into the regulatory networks connecting TGF-β and netrin-1 pathways. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
H-1152 is an indirect inhibitor of netrin-1 through the inhibition of ROCK, a downstream effector of netrin-1 signaling. By targeting ROCK, H-1152 modulates netrin-1-mediated cellular processes, influencing cytoskeletal dynamics and cell motility. This indirect inhibition provides a valuable tool for studying the interconnected pathways governed by netrin-1, shedding light on its roles in neuronal development and other physiological contexts. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
LY2157299 is an indirect inhibitor of netrin-1 through the modulation of the TGF-β pathway. Acting as a selective TGF-β receptor inhibitor, LY2157299 alters downstream TGF-β cascades, impacting netrin-1-mediated cellular processes. This indirect inhibition provides insights into the intricate crosstalk between TGF-β and netrin-1 pathways, contributing to our understanding of netrin-1's roles in developmental processes and pathological conditions. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT 1864 is an indirect inhibitor of netrin-1 through the inhibition of Rac1, a downstream effector of netrin-1 signaling. By selectively targeting Rac1, EHT 1864 modulates netrin-1-mediated cellular processes, influencing cytoskeletal dynamics and migration. This indirect inhibition offers a pharmacological tool for studying the interconnected pathways governed by netrin-1, shedding light on its roles in neuronal development and other physiological contexts. | ||||||
SB-505124 | 694433-59-5 | sc-362794 sc-362794A | 10 mg 50 mg | $327.00 $1377.00 | 2 | |
SB 505124 is an indirect inhibitor of netrin-1 through the modulation of the TGF-β pathway. As a selective inhibitor of TGF-β type I receptors, SB 505124 impacts netrin-1 signaling by altering downstream TGF-β cascades. This indirect inhibition influences netrin-1-mediated cellular processes, providing insights into the regulatory networks connecting TGF-β and netrin-1 pathways. | ||||||
GSK 269962 | 850664-21-0 | sc-363279 sc-363279A | 10 mg 50 mg | $300.00 $1000.00 | 1 | |
GSK 269962A is an indirect inhibitor of netrin-1 through the inhibition of ROCK, a downstream effector of netrin-1 signaling. By targeting ROCK, GSK 269962A modulates netrin-1-mediated cellular processes, influencing cytoskeletal dynamics and cell motility. This indirect inhibition provides a valuable tool for studying the interconnected pathways governed by netrin-1, shedding light on its roles in neuronal development and other physiological contexts. | ||||||