NERF Antibody (224C4a): sc-130632

NERF Antibody (224C4a) is a mouse monoclonal IgG1 antibody that detects the NERF protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-NERF antibody (224C4a) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. NERF (224C4a) antibody enables investigation of a key member of the Ets transcription factor family, which plays a crucial role in regulating gene expression during various biological processes, including cell differentiation, proliferation, and apoptosis. Understanding the function of NERF is vital, as NERF (224C4a) monoclonal antibody helps reveal involvement in the transcriptional regulation of genes essential for normal cellular function and development. The Ets family, including NERF, is characterized by a highly conserved DNA-binding domain that allows these proteins to interact with specific DNA sequences, thereby influencing the transcription of target genes. This interaction is critical for maintaining cellular homeostasis and responding to external signals, making NERF a significant player in both normal physiology and disease states. Anti-NERF antibody (224C4a) helps researchers delve deeper into the mechanisms of gene regulation mediated by this transcription factor, furthering our understanding of its role in health and disease.

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NERF Antibody (224C4a) References:

1. Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.  |  Cho, JY., et al. 2004. J Biol Chem. 279: 19512-22. PMID: 14970218
2. Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells.  |  Xin, JH., et al. 1992. Genes Dev. 6: 481-96. PMID: 1547944
3. E74-like factor 2 regulates valosin-containing protein expression.  |  Zhang, B., et al. 2007. Biochem Biophys Res Commun. 356: 536-41. PMID: 17368566
4. The Drosophila 74EF early puff contains E74, a complex ecdysone-inducible gene that encodes two ets-related proteins.  |  Burtis, KC., et al. 1990. Cell. 61: 85-99. PMID: 2107982
5. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints.  |  Rao, VN., et al. 1989. Science. 244: 66-70. PMID: 2539641
6. Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein.  |  Ghysdael, J., et al. 1986. Proc Natl Acad Sci U S A. 83: 1714-8. PMID: 3006066
7. The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.  |  Kola, I., et al. 1993. Proc Natl Acad Sci U S A. 90: 7588-92. PMID: 7689222
8. Differentially spliced erg-3 product functions as a transcriptional activator.  |  Prasad, DD., et al. 1994. Oncogene. 9: 669-73. PMID: 8290279
9. Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation.  |  Pongubala, JM., et al. 1993. Science. 259: 1622-5. PMID: 8456286

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NERF Antibody (224C4a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-NERF Antibody (224C4a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NERF Antibody (224C4a) Specifications

Alternate Product Name: NERF

Product Clone Name: 224C4a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: NERF

Epitope Species: human

Product Reactivity/Detection: NERF

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for NERF Antibody (224C4a): N/A