nephrocystin-3 Antibody (3B1): sc-517129

nephrocystin-3 Antibody (3B1) is a mouse monoclonal IgG1 kappa light chain antibody that detects nephrocystin-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-nephrocystin-3 antibody (3B1) is available as the non-conjugated format. Nephrocystin-3, encoded by the NPHP3 gene, plays a crucial role in renal tubular function and development, making nephrocystin-3 significant for understanding kidney health and disease. Nephrocystin-3 interacts with various signaling molecules, including p130Cas (BCAR1), proline-rich tyrosine kinases, calmodulin, and tensin, suggesting involvement in critical cellular signaling pathways that regulate cell adhesion and migration. Nephrocystin-3 contains distinct structural domains, including a tubulin-tyrosine ligase (TTL) domain, a coiled-coil (CC) domain, and a tetratrico peptide repeat (TPR) domain, which are essential for functional interactions and stability. Nephrocystin-3 is expressed at low levels across various tissues, including heart, placenta, liver, skeletal muscle, kidney, and pancreas, while showing minimal expression in brain and lung. Mutations in the NPHP3 gene can lead to nephronophthisis type 3, a recessive disorder that manifests in adolescents with severe renal complications, including sclerosing tubulointerstitial nephropathy and renal cyst development, ultimately resulting in chronic renal failure. The nephrocystin family, including nephrocystin-3, is vital for maintaining kidney function, and understanding these interactions and mechanisms can provide insights into potential therapeutic targets for kidney diseases.

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nephrocystin-3 Antibody (3B1) References:

1. Identification of a new gene locus for adolescent nephronophthisis, on chromosome 3q22 in a large Venezuelan pedigree.  |  Omran, H., et al. 2000. Am J Hum Genet. 66: 118-27. PMID: 10631142
2. Human adolescent nephronophthisis: gene locus synteny with polycystic kidney disease in pcy mice.  |  Omran, H., et al. 2001. J Am Soc Nephrol. 12: 107-113. PMID: 11134256
3. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis.  |  Olbrich, H., et al. 2003. Nat Genet. 34: 455-9. PMID: 12872122
4. Dietary potassium citrate does not harm the pcy mouse.  |  Tanner, JA. and Tanner, GA. 2005. Exp Biol Med (Maywood). 230: 57-60. PMID: 15618126

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-nephrocystin-3 Antibody (3B1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-nephrocystin-3 Antibody (3B1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

nephrocystin-3 Antibody (3B1) Specifications

Alternate Product Name: nephrocystin-3

Product Clone Name: 3B1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 106-205

Epitope Target: nephrocystin-3

Epitope Species: human

Product Reactivity/Detection: nephrocystin-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for nephrocystin-3 Antibody (3B1): N/A