NEGR1 Antibody (H-12): sc-393293
- NEGR1 Antibody (H-12) is a mouse monoclonal IgG1 κ NEGR1 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 38-218 mapping near the N-terminus of NEGR1 of human origin
- NEGR1 Antibody (H-12) is recommended for detection of NEGR1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-NEGR1 Antibody (H-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NEGR1 Antibody (H-12) for WB applications. These reagents are now offered in bundles with NEGR1 Antibody (H-12) (see ordering information below).
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SEE ALSO...
NEGR1 Antibody (H-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects NEGR1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-NEGR1 antibody (H-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NEGR1, also known as neuronal growth regulator 1, neurotractin, IGLON4, Ntra, DMML2433, or KILON, is a 354 amino acid protein that belongs to the IgLON family and the immunoglobulin superfamily. NEGR1 plays a crucial role in cell adhesion and is involved in regenerative axon sprouting in the mammalian brain, which is vital for neural repair and recovery following injury. NEGR1 is predominantly expressed in the adult hippocampus, cerebrum, and brainstem, with significantly lower expression levels in the cerebellum. NEGR1 localizes to the cell membrane via a glycosylphosphatidylinositol anchor and features three immunoglobulin-like C2-type domains, which are essential for its function in mediating cell-cell interactions. The NEGR1 gene is located on human chromosome 1p31.1 and is associated with several loci linked to body mass index (BMI), suggesting its potential role in obesity development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NEGR1 Antibody (H-12) References:
- Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family. | Funatsu, N., et al. 1999. J Biol Chem. 274: 8224-30. PMID: 10075727
- Biochemical and ultrastructural analyses of IgLON cell adhesion molecules, Kilon and OBCAM in the rat brain. | Miyata, S., et al. 2003. Neuroscience. 117: 645-58. PMID: 12617969
- Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. | Schäfer, M., et al. 2005. Mol Cell Neurosci. 29: 580-90. PMID: 15946856
- Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. | Thorleifsson, G., et al. 2009. Nat Genet. 41: 18-24. PMID: 19079260
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. | Willer, CJ., et al. 2009. Nat Genet. 41: 25-34. PMID: 19079261
- Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. | Bauer, F., et al. 2009. Am J Clin Nutr. 90: 951-9. PMID: 19692490
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NEGR1 Antibody (H-12) | sc-393293 | 200 µg/ml | $322.00 | |||
NEGR1 Antibody (H-12): m-IgG Fc BP-HRP Bundle | sc-530421 | 200 µg Ab; 10 µg BP | $361.00 | |||
NEGR1 Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-523891 | 200 µg Ab, 40 µg BP | $361.00 | |||
NEGR1 Antibody (H-12): m-IgG1 BP-HRP Bundle | sc-544044 | 200 µg Ab; 20 µg BP | $361.00 | |||
NEGR1 Antibody (H-12) AC | sc-393293 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NEGR1 Antibody (H-12) HRP | sc-393293 HRP | 200 µg/ml | $322.00 | |||
NEGR1 Antibody (H-12) FITC | sc-393293 FITC | 200 µg/ml | $336.00 | |||
NEGR1 Antibody (H-12) PE | sc-393293 PE | 200 µg/ml | $349.00 | |||
NEGR1 Antibody (H-12) Alexa Fluor® 488 | sc-393293 AF488 | 200 µg/ml | $364.00 | |||
NEGR1 Antibody (H-12) Alexa Fluor® 546 | sc-393293 AF546 | 200 µg/ml | $364.00 | |||
NEGR1 Antibody (H-12) Alexa Fluor® 594 | sc-393293 AF594 | 200 µg/ml | $364.00 | |||
NEGR1 Antibody (H-12) Alexa Fluor® 647 | sc-393293 AF647 | 200 µg/ml | $364.00 | |||
NEGR1 Antibody (H-12) Alexa Fluor® 680 | sc-393293 AF680 | 200 µg/ml | $364.00 | |||
NEGR1 Antibody (H-12) Alexa Fluor® 790 | sc-393293 AF790 | 200 µg/ml | $364.00 |