NEDD1 Antibody (39-J): sc-100961

NEDD1 Antibody (39-J) is a mouse monoclonal IgG2b antibody that detects NEDD1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). NEDD1, also known as neural precursor cell expressed, developmentally down-regulated 1 or GCP-WD, is a crucial component of the γ-tubulin ring complex (γTuRC) and is essential for proper mitotic spindle formation and microtubule nucleation. NEDD1 is characterized by eight WD40 repeats and a coiled-coil domain at the C-terminus, which are vital for structural integrity and function. During mitosis, NEDD1 undergoes phosphorylation, a post-translational modification that regulates activity and influences localization within the cell. This phosphorylation is critical for the recruitment of γ-tubulin to the centrosome and spindle, thereby facilitating the assembly of microtubules necessary for chromosome segregation. Disruption of NEDD1 function can lead to impaired microtubule dynamics, highlighting NEDD1′s potential as a target for therapeutic interventions in cancer, where mitotic regulation is often compromised. With broad species reactivity and versatility in various applications, anti-NEDD1 antibody (39-J) is an invaluable tool for researchers studying cell division and its implications in disease.

The preferred NEDD1 antibody is NEDD1 Antibody (H-3): sc-398733.