Nectin 1 Antibody (R1.302.12): sc-69718
- Nectin 1 Antibody (R1.302.12) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against NIH3T3 cells transfected with Nectin 1 of human origin
- recommended for detection of Nectin 1 of human origin by WB, IP, IF, IHC(P) and FCM; may cross-react with Nectin 1 of monkey origin; non cross-reactive with Nectin 1 of mouse and rat origin
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See Nectin 1 (CK6): sc-21722 for Nectin 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Nectin 1 Antibody (R1.302.12) for WB and IHC(P) applications. These reagents are now offered in bundles with Nectin 1 Antibody (R1.302.12) (see ordering information below).
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Nectin 1 Antibody (R1.302.12) is a mouse monoclonal IgG1 antibody that detects Nectin 1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Nectin 1 is a crucial member of the Nectin family, which plays a significant role in cell adhesion and communication, particularly in the nervous system where Nectin 1 is abundantly expressed. Nectin 1 is essential for the formation of adherens junctions, which are critical for maintaining tissue integrity and facilitating intercellular signaling. Nectin 1 interacts with other proteins, such as afadin, which links Nectin 1 to the actin cytoskeleton, thereby influencing cellular morphology and motility. Proper functioning of Nectin 1 is vital for processes such as synapse formation and maintenance, making Nectin 1 a key player in both neural development and immune response. Anti-Nectin 1 antibody (R1.302.12) is an invaluable tool for researchers studying these processes and the underlying mechanisms of various diseases, including viral infections and neurodegenerative disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Nectin 1 Antibody (R1.302.12) References:
- Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. | Inagaki, M., et al. 2005. Development. 132: 1525-37. PMID: 15728677
- Expression of nectin-1, nectin-3, N-cadherin, and NCAM in spinal motoneurons after sciatic nerve transection. | Zelano, J., et al. 2006. Exp Neurol. 201: 461-9. PMID: 16777094
- Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth. | Yoshida, T., et al. 2010. Dev Dyn. 239: 2558-69. PMID: 21038445
- Herpesvirus entry mediator and nectin-1 mediate herpes simplex virus 1 infection of the murine cornea. | Karaba, AH., et al. 2011. J Virol. 85: 10041-7. PMID: 21795335
- Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia. | Shukla, ND., et al. 2012. Mol Vis. 18: 2711-6. PMID: 23213272
- Nectin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb. | Inoue, T., et al. 2015. J Comp Neurol. 523: 1824-39. PMID: 25967681
- Herpes simplex virus glycoprotein D relocates nectin-1 from intercellular contacts. | Bhargava, AK., et al. 2016. Virology. 499: 267-277. PMID: 27723487
- Sevoflurane-induced learning deficits and spine loss via nectin-1/corticotrophin-releasing hormone receptor type 1 signaling. | Li, Y., et al. 2019. Brain Res. 1710: 188-198. PMID: 30529655
- Nectin-1 Expression Correlates with the Susceptibility of Malignant Melanoma to Oncolytic Herpes Simplex Virus In Vitro and In Vivo. | Schwertner, B., et al. 2021. Cancers (Basel). 13: PMID: 34205379
- Single amino acid mutation of nectin-1 provides remarkable resistance against lethal pseudorabies virus infection in mice. | Tomioka, Y., et al. 2024. J Vet Med Sci. 86: 120-127. PMID: 38030279
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nectin 1 Antibody (R1.302.12) | sc-69718 | 200 µg/ml | $322.00 | |||
Nectin 1 Antibody (R1.302.12): m-IgG Fc BP-HRP Bundle | sc-539228 | 200 µg Ab; 10 µg BP | $361.00 | |||
Nectin 1 Antibody (R1.302.12): m-IgG1 BP-HRP Bundle | sc-541339 | 200 µg Ab; 20 µg BP | $361.00 | |||
Nectin 1 Antibody (R1.302.12) FITC | sc-69718 FITC | 200 µg/ml | $336.00 | |||
Nectin 1 Antibody (R1.302.12) PE | sc-69718 PE | 200 µg/ml | $349.00 |