NDST1 Antibody (FF-2): sc-100790

NDST1 Antibody (FF-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects NDST1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-NDST1 antibody (FF-2) is available in a non-conjugated form, providing flexibility for various experimental needs. NDST1 plays a crucial role in the modification of heparan sulfate and heparin through N-deacetylation and N-sulfation of N-acetylglucosamine residues, which are essential for synthesizing oligosaccharide sequences with specific ligand-binding properties. These modifications are vital for numerous biological processes, including cell signaling, development, and regulation of cell-matrix interactions. NDST1 is part of a family of GlcNAc N-deacetylase/N-sulfotransferases, sharing significant homology with NDST2, while NDST3 and NDST4 exhibit a more restricted expression pattern in various tissues. Understanding NDST1 function and interactions with other proteins is important for elucidating NDST1′s role in health and disease, particularly in conditions where glycosaminoglycan modifications are disrupted.

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NDST1 Antibody (FF-2) References:

1. Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.  |  Aikawa, J., et al. 2001. J Biol Chem. 276: 5876-82. PMID: 11087757
2. Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1.  |  Dixon, J., et al. 1995. Genomics. 26: 239-44. PMID: 7601448
3. cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2.  |  Humphries, DE., et al. 1998. Biochem J. 332 (Pt 2): 303-7. PMID: 9601056
4. Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.  |  Aikawa, J. and Esko, JD. 1999. J Biol Chem. 274: 2690-5. PMID: 9915799

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NDST1 Antibody (FF-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-NDST1 Antibody (FF-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NDST1 Antibody (FF-2) Specifications

Alternate Product Name: NDST1

Product Clone Name: FF-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 38-137

Epitope Target: NDST1

Epitope Species: human

Product Reactivity/Detection: NDST1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for NDST1 Antibody (FF-2): N/A