NCoA-7 Antibody (C-2): sc-393427
- NCoA-7 Antibody (C-2) is a mouse monoclonal IgG1 κ NCoA-7 antibody provided at 200 µg/ml
- raised against amino acids 601-900 mapping near the C-terminus of NCoA-7 of human origin
- NCoA-7 Antibody (C-2) is recommended for detection of NCoA-7 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-NCoA-7 Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NCoA-7 Antibody (C-2) for WB applications. These reagents are now offered in bundles with NCoA-7 Antibody (C-2) (see ordering information below).
NCoA-7 Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects NCoA-7 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NCoA-7 (C-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NCoA-7, also known as nuclear receptor coactivator 7, ESNA1, or ERAP140, is a crucial 942 amino acid nuclear protein that enhances transcriptional activities of nuclear receptors, such as PPARγ, ERα, TRβ1, and RARα, influencing gene expression in response to hormonal signals. NCoA-7 is predominantly expressed in the brain, with lower levels found in tissues such as pancreas, bladder, ovary, spinal cord, prostate, mammary gland, uterus, and stomach, highlighting NCoA-7′s importance in various physiological processes. As a member of the OXR1 family, NCoA-7 features a LysM repeat and a TLD domain, which are essential for interaction with other proteins and functional role in transcriptional regulation. Located on human chromosome 6q22.31 and mouse chromosome 10 A4, NCoA-7 undergoes alternative splicing resulting in six known isoforms, underscoring NCoA-7′s complexity and regulatory potential in cellular signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NCoA-7 Antibody (C-2) References:
- Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. | Nguyen, TA., et al. 1999. Arch Biochem Biophys. 367: 250-7. PMID: 10395741
- ERAP140, a conserved tissue-specific nuclear receptor coactivator. | Shao, W., et al. 2002. Mol Cell Biol. 22: 3358-72. PMID: 11971969
- The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins. | Durand, M., et al. 2007. BMC Cell Biol. 8: 13. PMID: 17391516
- ERAP140/Nbla10993 is a novel favorable prognostic indicator for neuroblastoma induced in response to retinoic acid. | Arai, H., et al. 2008. Oncol Rep. 19: 1381-8. PMID: 18497940
- Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription. | Halachmi, S., et al. 1994. Science. 264: 1455-8. PMID: 8197458
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NCoA-7 Antibody (C-2) | sc-393427 | 200 µg/ml | $322.00 | |||
NCoA-7 Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-530453 | 200 µg Ab; 10 µg BP | $361.00 | |||
NCoA-7 Antibody (C-2): m-IgGκ BP-HRP Bundle | sc-523942 | 200 µg Ab, 40 µg BP | $361.00 | |||
NCoA-7 Antibody (C-2): m-IgG1 BP-HRP Bundle | sc-544058 | 200 µg Ab; 20 µg BP | $361.00 | |||
NCoA-7 Antibody (C-2) AC | sc-393427 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NCoA-7 Antibody (C-2) HRP | sc-393427 HRP | 200 µg/ml | $322.00 | |||
NCoA-7 Antibody (C-2) FITC | sc-393427 FITC | 200 µg/ml | $336.00 | |||
NCoA-7 Antibody (C-2) PE | sc-393427 PE | 200 µg/ml | $349.00 | |||
NCoA-7 Antibody (C-2) Alexa Fluor® 488 | sc-393427 AF488 | 200 µg/ml | $364.00 | |||
NCoA-7 Antibody (C-2) Alexa Fluor® 546 | sc-393427 AF546 | 200 µg/ml | $364.00 | |||
NCoA-7 Antibody (C-2) Alexa Fluor® 594 | sc-393427 AF594 | 200 µg/ml | $364.00 | |||
NCoA-7 Antibody (C-2) Alexa Fluor® 647 | sc-393427 AF647 | 200 µg/ml | $364.00 | |||
NCoA-7 Antibody (C-2) Alexa Fluor® 680 | sc-393427 AF680 | 200 µg/ml | $364.00 | |||
NCoA-7 Antibody (C-2) Alexa Fluor® 790 | sc-393427 AF790 | 200 µg/ml | $364.00 |