NCoA-3 Antibody (1A8): sc-80992

NCoA-3 Antibody (1A8) is a mouse monoclonal IgG1 antibody that detects NCoA-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). NCoA-3, also known as RAC3, ACTR, AIB-1, and p/CIP, plays a crucial role as a transcriptional coactivator in the steroid receptor family, facilitating the transcriptional activation of hormone-responsive genes. NCoA-3 is particularly significant due to its involvement in the regulation of gene expression linked to various physiological processes, including cell growth and differentiation. Notably, NCoA-3 is often overexpressed in estrogen receptor-positive ovarian and breast cancers, highlighting its importance in cancer biology and potential as a therapeutic target. The interaction of NCoA-3 with other proteins, such as p300/CBP, underscores its role in enhancing transcriptional activity, making NCoA-3 a vital component in the signaling pathways that govern cellular responses to hormones. By utilizing anti-NCoA-3 antibody (1A8), researchers can gain insights into the mechanisms of hormone action and the implications of NCoA-3 in oncogenesis, thereby advancing our understanding of cancer biology and potential treatment strategies.

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NCoA-3 Antibody (1A8) References:

1. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain.  |  De Langhe, S., et al. 2002. Int J Mol Med. 9: 451-9. PMID: 11956649
2. ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance.  |  Louie, MC., et al. 2004. Mol Cell Biol. 24: 5157-71. PMID: 15169882
3. Crystal structures of the Streptomyces coelicolor TetR-like protein ActR alone and in complex with actinorhodin or the actinorhodin biosynthetic precursor (S)-DNPA.  |  Willems, AR., et al. 2008. J Mol Biol. 376: 1377-87. PMID: 18207163
4. Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR/AIB1 overexpression in breast cancer.  |  Hsia, EY., et al. 2010. Mol Cancer Res. 8: 183-93. PMID: 20124470
5. Rac3 Regulates Cell Invasion, Migration and EMT in Lung Adenocarcinoma through p38 MAPK Pathway.  |  Zhang, C., et al. 2017. J Cancer. 8: 2511-2522. PMID: 28900489
6. MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation.  |  Li, Y., et al. 2018. Mol Oncol. 12: 391-405. PMID: 29360267
7. Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons.  |  Pennucci, R., et al. 2019. PLoS One. 14: e0220496. PMID: 31369617
8. NR5A2 synergizes with NCOA3 to induce breast cancer resistance to BET inhibitor by upregulating NRF2 to attenuate ferroptosis.  |  Qiao, J., et al. 2020. Biochem Biophys Res Commun. 530: 402-409. PMID: 32536370
9. RAC3 Inhibition Induces Autophagy to Impair Metastasis in Bladder Cancer Cells via the PI3K/AKT/mTOR Pathway.  |  Wang, L., et al. 2022. Front Oncol. 12: 915240. PMID: 35847878
10. SETD8 inhibits apoptosis and ferroptosis of Ewing's sarcoma through YBX1/RAC3 axis.  |  Chen, H., et al. 2024. Cell Death Dis. 15: 494. PMID: 38987564

The preferred NCoA-3 antibody is NCoA-3 Antibody (F-2): sc-5305.