NCAM/CD56 Antibody (ERIC 1): sc-106

NCAM Antibody (ERIC 1) is a mouse monoclonal IgG1 kappa light chain antibody targeting Neural Cell Adhesion Molecule (NCAM), also known as CD56 or NCAM1. Engineered to recognize NCAM of human origin, anti-NCAM antibody (ERIC 1) is ideal for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM), while exhibiting no cross-reactivity with mouse NCAM. NCAM is a critical cell surface glycoprotein involved in mediating cell-cell interactions essential for neuronal development, including processes like embryogenesis, neural migration, and synaptic plasticity. These functions are vital for the proper formation and maintenance of the nervous system, underscoring NCAM′s importance in both developmental biology and neurobiology. Additionally, NCAM is expressed in various human tumors such as neuroblastomas, rhabdomyosarcomas, Wilms′ tumor, Ewing′s sarcoma, and certain myeloid malignancies, making NCAM a valuable biomarker for cancer research and diagnostics. NCAM (ERIC 1) monoclonal antibody recognizes multiple isoforms of NCAM generated through alternative splicing and polyadenylation of the single NCAM gene located on chromosome 11q23. With robust performance and reliability, NCAM (ERIC 1) antibody is an essential tool for researchers investigating neural development, cancer biology, and cellular adhesion mechanisms. Anti-NCAM antibody (ERIC 1) is available in both conjugated and unconjugated forms, providing flexibility to meet diverse experimental requirements.

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NCAM/CD56 Antibody (ERIC 1) References:

1. Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.  |  Phimister, E., et al. 1991. J Clin Pathol. 44: 580-5. PMID: 1856291
2. A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm.  |  Bourne, SP., et al. 1991. J Neurooncol. 10: 111-9. PMID: 1895159
3. NCAM in neuropsychiatric and neurodegenerative disorders.  |  Brennaman, LH. and Maness, PF. 2010. Adv Exp Med Biol. 663: 299-317. PMID: 20017030
4. The N-cam gene is a complex transcriptional unit.  |  Walsh, FS. 1988. Neurochem Int. 12: 263-7. PMID: 20501228
5. Differential spectrum of expression of neural cell adhesion molecule isoforms and L1 adhesion molecules on human neuroectodermal tumors.  |  Figarella-Branger, DF., et al. 1990. Cancer Res. 50: 6364-70. PMID: 2400996
6. Presence of the long chain form of polysialic acid of the neural cell adhesion molecule in Wilms' tumor. Identification of a cell adhesion molecule as an oncodevelopmental antigen and implications for tumor histogenesis.  |  Roth, J., et al. 1988. Am J Pathol. 133: 227-40. PMID: 2461089
7. Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule.  |  Lanier, LL., et al. 1989. J Exp Med. 169: 2233-8. PMID: 2471777
8. NCAM Mimetic Peptides: Potential Therapeutic Target for Neurological Disorders.  |  Chu, C., et al. 2018. Neurochem Res. 43: 1714-1722. PMID: 30003388
9. Characterization of neural cell adhesion molecules (NCAM) expressed by Ewing and neuroblastoma cell lines.  |  Lipinski, M., et al. 1987. Int J Cancer. 40: 81-6. PMID: 3036723
10. Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing.  |  Cunningham, BA., et al. 1987. Science. 236: 799-806. PMID: 3576199
11. Schizophrenia as autoimmune disease: Involvement of Anti-NCAM antibodies.  |  Khlidj, Y. and Haireche, MA. 2023. J Psychiatr Res. 161: 333-341. PMID: 37001338
12. Cell adhesion and the molecular processes of morphogenesis.  |  Edelman, GM. 1985. Annu Rev Biochem. 54: 135-69. PMID: 3896119

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NCAM/CD56 Antibody (ERIC 1) has 69 citations in a variety of scientific publications.

Primary antibodies like Anti-NCAM/CD56 Antibody (ERIC 1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NCAM/CD56 Antibody (ERIC 1) Specifications

Alternate Product Name: CD56

Product Clone Name: ERIC 1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: NCAM

Epitope Species: human

Product Reactivity/Detection: NCAM

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 69 citations in various scientific publications

Available Conjugates/Forms for NCAM/CD56 Antibody (ERIC 1): AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, PE: Phycoerythrin