NAT-10 Antibody (D-5): sc-271142
- NAT-10 Antibody (D-5) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against a peptide mapping within an internal region of NAT-10 of human origin
- recommended for detection of NAT-10 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NAT-10 Antibody (D-5) for WB applications. These reagents are now offered in bundles with NAT-10 Antibody (D-5) (see ordering information below).
NAT-10 Antibody (D-5) is a mouse monoclonal IgG2b antibody that detects NAT-10 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NAT-10, also known as N-acetyltransferase 10, is a crucial nuclear protein that plays a significant role in regulating telomerase activity, particularly in response to DNA damage. NAT-10 is characterized by its single N-acetyltransferase domain, which functions as a histone acetyltransferase, thereby influencing chromatin structure and gene expression. NAT-10′s importance lies in binding to the promoter region of the telomerase reverse transcriptase (TERT) gene, thereby stimulating telomerase production, which is essential for maintaining telomere length and genomic stability. This regulatory mechanism is vital for cellular longevity and resistance to genotoxic stress, highlighting the multifaceted roles of human telomerase complexes beyond mere telomere maintenance. NAT-10 (D-5) antibody is an invaluable tool for researchers investigating the intricate pathways of DNA repair and telomere biology.
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NAT-10 Antibody (D-5) References:
- NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1. | Zhang, Y., et al. 2021. Signal Transduct Target Ther. 6: 173. PMID: 33941767
- NAT10-mediated N4-acetylcytidine modification is required for meiosis entry and progression in male germ cells. | Chen, L., et al. 2022. Nucleic Acids Res. 50: 10896-10913. PMID: 35801907
- NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma. | Wei, R., et al. 2022. Acta Pharm Sin B. 12: 3313-3325. PMID: 35967285
- NAT10 regulates neutrophil pyroptosis in sepsis via acetylating ULK1 RNA and activating STING pathway. | Zhang, H., et al. 2022. Commun Biol. 5: 916. PMID: 36068299
- Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression. | Deng, M., et al. 2023. J Exp Clin Cancer Res. 42: 9. PMID: 36609449
- NAT10 accelerates pulmonary fibrosis through N4-acetylated TGFB1-initiated epithelial-to-mesenchymal transition upon ambient fine particulate matter exposure. | Shenshen Wu,., et al. 2023. Environ Pollut. 322: 121149. PMID: 36731737
- N4-Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF-1α Positive Feedback Loop. | Yang, Q., et al. 2023. Adv Sci (Weinh). 10: e2300898. PMID: 37328448
- The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury. | Qu, Z., et al. 2024. Redox Biol. 72: 103145. PMID: 38583415
- Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis. | Zou, Y., et al. 2024. Cell Rep Med. 5: 101728. PMID: 39293390
- NAT10 promotes vascular remodelling via mRNA ac4C acetylation. | Yu, C., et al. 2025. Eur Heart J. 46: 288-304. PMID: 39453784
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NAT-10 Antibody (D-5) | sc-271142 | 200 µg/ml | $322.00 | |||
NAT-10 Antibody (D-5): m-IgGκ BP-HRP Bundle | sc-534878 | 200 µg Ab; 40 µg BP | $361.00 | |||
NAT-10 Antibody (D-5): m-IgG2b BP-HRP Bundle | sc-549310 | 200 µg Ab; 10 µg BP | $361.00 | |||
NAT-10 (D-5) Neutralizing Peptide | sc-271142 P | 100 µg/0.5 ml | $69.00 |