nardilysin Antibody (A-8): sc-514955

nardilysin Antibody (A-8) is a mouse monoclonal IgG1 antibody that detects nardilysin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nardilysin is a 1,147 amino acid metalloendopeptidase that plays a crucial role in the activation of protein precursors by cleaving propeptide and proprotein substrates at the amino-terminus of arginine residues in dibasic moieties. Nardilysin is primarily expressed in adult heart, skeletal muscle, and testis, with expression in the testis being restricted to germ cells, highlighting its importance in reproductive biology. As a member of the insulinase family, nardilysin serves as a specific receptor for heparin-binding epidermal growth factor-like growth factor (HB-EGF), which is essential for modulating HB-EGF-induced cell migration via the ErbB1 pathway, thereby influencing cellular processes such as growth and differentiation. The nardilysin gene is located on chromosome 1p32.2, and defects in this gene have been linked to inherited neuromuscular disorders, underscoring the significance of nardilysin in both normal physiology and disease states. anti-nardilysin antibody (A-8) is an invaluable tool for researchers investigating the functional roles of this protease in various biological contexts.

The preferred nardilysin antibody is nardilysin Antibody (A-6): sc-137199.