NACAD Antibody (H-4): sc-515113

NACAD Antibody (H-4) is a mouse monoclonal IgM antibody that detects NACAD of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NACAD (H-4) antibody is available as the non-conjugated form. NACAD, which consists of 1,562 amino acids, plays a crucial role in cellular function by preventing non-secretory polypeptides from misdirecting to the endoplasmic reticulum, thereby ensuring proper protein sorting and secretion. NACAD is localized in both the cytoplasm and nucleus, highlighting its importance in various cellular processes. As a member of the NAC-alpha family, NACAD contains one NAC-A/B (NAC-alpha/beta) domain, which is essential for its function. The gene encoding NACAD is located on human chromosome 7, a region that is significant not only for its large number of genes—over 1,000—but also for its association with various genetic disorders, including Osteogenesis imperfecta and Shwachman-Diamond syndrome. Notably, deletions in the q arm of chromosome 7 have been linked to Williams-Beuren syndrome, characterized by unique behavioral traits and physical features, as well as several myeloid disorders, including acute myelogenous leukemia. NACAD (H-4) antibody thus serves as a valuable tool for researchers studying the intricate roles of NACAD in health and disease.

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NACAD Antibody (H-4) References:

1. Long-term audiological feature in Pendred syndrome caused by PDS mutation.  |  Iwasaki, S., et al. 2001. Arch Otolaryngol Head Neck Surg. 127: 705-8. PMID: 11405873
2. Williams-Beuren syndrome diagnosis using fluorescence in situ hybridization.  |  Osborne, LR., et al. 2006. Methods Mol Med. 126: 113-28. PMID: 16930009
3. Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more.  |  Reiner, O., et al. 2006. Neuromolecular Med. 8: 547-65. PMID: 17028375
4. [Williams-Beuren syndrome].  |  Gilbert-Dussardier, B. 2006. Rev Prat. 56: 2102-6. PMID: 17416045
5. Therapy-related leukemia and myelodysplasia: susceptibility and incidence.  |  Leone, G., et al. 2007. Haematologica. 92: 1389-98. PMID: 17768113
6. Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta.  |  Tsipouras, P., et al. 1983. J Clin Invest. 72: 1262-7. PMID: 6313757
7. Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: evidence for multiple critical loci.  |  Liang, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 3781-5. PMID: 9520444

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NACAD Antibody (H-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-NACAD Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NACAD Antibody (H-4) Specifications

Alternate Product Name: NACAD

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 59-79

Epitope Target: NACAD

Epitope Species: human

Product Reactivity/Detection: NACAD

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for NACAD Antibody (H-4): P: Blocking Peptide