NACAD Inhibitors
NACAD Inhibitors are a group of chemical compounds that primarily target the intracellular transport mechanisms and cellular signaling pathways that NACAD is directly involved in. Inhibitors that disrupt the structure and function of the Golgi apparatus, such as Brefeldin A, or inhibit the transport of vesicles to the plasma membrane, such as Exo2, can impede the trafficking of NACAD to the nucleus, thereby leading to its functional inhibition. Similarly, compounds that affect actin dynamics, such as Latrunculin A, Cytochalasin D, and Jasplakinolide, or that impact microtubule dynamics, such as Nocodazole and Paclitaxel, can disrupt the transport and localization of NACAD, leading to decreased functional activity.
On the other hand, inhibitors of PI3K and mTOR, such as LY294002, Wortmannin, and Rapamycin, and the phospholipase C inhibitor U73122, can indirectly affect NACAD's function by altering cellular signaling that could influence NACAD's biological processes. Pervanadate, an inhibitor of protein tyrosine phosphatases, can affect the regulatory function of phosphoproteins, thereby altering the functionality of NACAD.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes F-actin, disrupting actin dynamics. This can affect the trafficking and localization of NACAD, subsequently leading to decreased functional activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole depolymerizes microtubules, disrupting intracellular transport mechanisms, potentially affecting the localization and function of NACAD. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules, altering intracellular transport mechanisms, potentially affecting the localization and function of NACAD. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, a key enzyme in the PI3K/Akt pathway. By inhibiting PI3K, it can indirectly affect NACAD’s function by altering cellular signaling that could influence NACAD's biological processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key protein in the PI3K/Akt pathway. By inhibiting mTOR, it can indirectly affect NACAD’s function by altering cellular signaling that could influence NACAD's biological processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent, irreversible inhibitor of PI3K, a key enzyme in the PI3K/Akt pathway. It can indirectly inhibit NACAD by altering cellular signaling that could influence NACAD's biological processes. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Pervanadate inhibits protein tyrosine phosphatases, involved in the regulation of phosphoprotein function. By inhibiting these phosphatases, it can indirectly affect the functional activity of NACAD by altering cellular signaling that could influence NACAD's biological processes. | ||||||