alpha 3 Sodium Potassium ATPase/ATP1A3 Antibody (6D135): sc-71640

Na+/K+-ATPase α3 Antibody (6D135) is a mouse monoclonal IgG1 antibody that detects Na+/K+-ATPase α3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Na+/K+-ATPase α3 is a vital component of the sodium/potassium-ATPase complex, which maintains cellular homeostasis by regulating ion gradients across the plasma membrane. Na+/K+-ATPase α3 is predominantly located in the plasma membrane of various cell types, where Na+/K+-ATPase α3 plays a significant role in controlling cellular volume and membrane potential. Proper functioning of Na+/K+-ATPase α3 is essential for numerous physiological processes, including muscle contraction, nerve impulse transmission, and nutrient absorption. Disruption of Na+/K+-ATPase α3 activity can lead to severe pathophysiological conditions, such as hypertension and heart failure. The Na+/K+-ATPase complex is composed of multiple isoforms, with the α subunit being responsible for ATP binding and cation transport, while the β subunit is crucial for the correct folding and membrane insertion of the α subunit. The interaction between these subunits ensures the efficient functioning of the pump, highlighting Na+/K+-ATPase α3′s importance in cellular physiology and potential as a therapeutic target in various diseases.

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alpha 3 Sodium Potassium ATPase/ATP1A3 Antibody (6D135) References:

1. Preferential reduction of Na+/K+ ATPase alpha3 by 17beta-estradiol influences contraction frequency in rat uteri.  |  Tsai, ML., et al. 2000. Chin J Physiol. 43: 1-8. PMID: 10857462
2. Identification of thyroid regulatory elements in the Na-K-ATPase alpha3 gene promoter.  |  Bajpai, M., et al. 2001. Mol Biol Rep. 28: 1-7. PMID: 11710559
3. Mutations in the Na+/K+ -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism.  |  de Carvalho Aguiar, P., et al. 2004. Neuron. 43: 169-75. PMID: 15260953
4. The Na, K-ATPase alpha3-isoform specifically localizes in the Schmidt-Lanterman incisures of human nerve.  |  Rigoard, P., et al. 2007. Cell Mol Biol (Noisy-le-grand). 53 Suppl: OL1003-9. PMID: 18184478
5. Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades.  |  Chan, SH., et al. 2013. Biochem Pharmacol. 86: 1564-75. PMID: 24099795
6. Attenuation of mania-like behavior in Na(+),K(+)-ATPase α3 mutant mice by prospective therapies for bipolar disorder: melatonin and exercise.  |  Kirshenbaum, GS., et al. 2014. Neuroscience. 260: 195-204. PMID: 24342563
7. Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station.  |  DiChiara, T., et al. 2017. Yale J Biol Med. 90: 45-61. PMID: 28356893
8. Na+, K+-ATPase α3 isoform in frontal cortex GABAergic neurons in psychiatric diseases.  |  Hodes, A., et al. 2019. J Psychiatr Res. 115: 21-28. PMID: 31082653
9. Promoter of the Na,K-ATPase alpha3 subunit gene is composed of cis elements to which NF-Y and Sp1/Sp3 bind in rat cardiocytes.  |  Murakami, Y., et al. 1997. Biochim Biophys Acta. 1352: 311-24. PMID: 9224955
10. Selective induction of Na,K-ATPase alpha3 subunit mRNA abundance in cardiac myocytes by retinoic acid.  |  Chin, S., et al. 1998. J Mol Cell Cardiol. 30: 2403-10. PMID: 9925375

The preferred ATP1A1/ATP1A2/ATP1A3 antibody is ATP1A1/ATP1A2/ATP1A3 Antibody (H-3): sc-48345.