alpha 3 Sodium Potassium ATPase/ATP1A3 Antibody (6D135): sc-71640

Na+/K+-ATPase α3 Antibody (6D135) is a mouse monoclonal IgG1 antibody that detects Na+/K+-ATPase α3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Na+/K+-ATPase α3 is a vital component of the sodium/potassium-ATPase complex, which maintains cellular homeostasis by regulating ion gradients across the plasma membrane. Na+/K+-ATPase α3 is predominantly located in the plasma membrane of various cell types, where Na+/K+-ATPase α3 plays a significant role in controlling cellular volume and membrane potential. Proper functioning of Na+/K+-ATPase α3 is essential for numerous physiological processes, including muscle contraction, nerve impulse transmission, and nutrient absorption. Disruption of Na+/K+-ATPase α3 activity can lead to severe pathophysiological conditions, such as hypertension and heart failure. The Na+/K+-ATPase complex is composed of multiple isoforms, with the α subunit being responsible for ATP binding and cation transport, while the β subunit is crucial for the correct folding and membrane insertion of the α subunit. The interaction between these subunits ensures the efficient functioning of the pump, highlighting Na+/K+-ATPase α3′s importance in cellular physiology and potential as a therapeutic target in various diseases.

The preferred ATP1A1/ATP1A2/ATP1A3 antibody is ATP1A1/ATP1A2/ATP1A3 Antibody (H-3): sc-48345.