beta 3 Sodium Potassium ATPase/ATP1B3 Antibody (46): sc-135998

Na+/K+-ATPase β3 Antibody (46) is a mouse monoclonal IgG1 kappa light chain antibody that detects Na+/K+-ATPase beta 3 protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Na+/K+-ATPase β3 (46) monoclonal antibody is available as the non-conjugated isotype antibody. Na+/K+-ATPase beta 3 protein is a crucial component of the sodium/potassium-ATPase complex, which is essential for maintaining cellular homeostasis. Na+/K+-ATPase beta 3 protein is primarily located in the plasma membrane of cells, where Na+/K+-ATPase beta 3 plays a vital role in regulating ion gradients by transporting sodium and potassium ions across the membrane. Proper functioning of Na+/K+-ATPase beta 3 is critical for various physiological processes, including maintenance of resting membrane potential, cellular volume regulation, and facilitation of secondary active transport mechanisms. Disruption of Na+/K+-ATPase beta 3 function can lead to severe cellular dysfunction and is implicated in various pathophysiological conditions, including hypertension and heart failure. The β subunit of Na+/K+-ATPase complex not only aids in correct folding and membrane insertion of the α subunit but also plays a significant role in overall stability and activity of the enzyme, making Na+/K+-ATPase beta 3 a key target for research in cellular physiology and disease mechanisms.

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beta 3 Sodium Potassium ATPase/ATP1B3 Antibody (46) References:

1. Functional role and immunocytochemical localization of the gamma a and gamma b forms of the Na,K-ATPase gamma subunit.  |  Pu, HX., et al. 2001. J Biol Chem. 276: 20370-8. PMID: 11278761
2. Chemical modification as an approach to elucidation of sodium pump structure-function relations.  |  Pedemonte, CH. and Kaplan, JH. 1990. Am J Physiol. 258: C1-23. PMID: 2154108
3. The sodium pump needs its beta subunit.  |  McDonough, AA., et al. 1990. FASEB J. 4: 1598-605. PMID: 2156741
4. Mutual dependence of Na,K-ATPase alpha- and beta-subunits for correct posttranslational processing and intracellular transport.  |  Ackermann, U. and Geering, K. 1990. FEBS Lett. 269: 105-8. PMID: 2167238
5. A proteolipid associated with Na,K-ATPase is not essential for ATPase activity.  |  Hardwicke, PM. and Freytag, JW. 1981. Biochem Biophys Res Commun. 102: 250-7. PMID: 6272791
6. Functional significance of the beta-subunit for heterodimeric P-type ATPases.  |  Chow, DC. and Forte, JG. 1995. J Exp Biol. 198: 1-17. PMID: 7891030
7. Na+,K(+)-ATPase.  |  Lingrel, JB. and Kuntzweiler, T. 1994. J Biol Chem. 269: 19659-62. PMID: 8051040
8. Subunit requirements for expression of functional sodium pumps in yeast cells.  |  Scheiner-Bobis, G. and Farley, RA. 1994. Biochim Biophys Acta. 1193: 226-34. PMID: 8054343
9. The alpha-subunit of the Na,K-ATPase has catalytic activity independent of the beta-subunit.  |  Blanco, G., et al. 1994. J Biol Chem. 269: 23420-5. PMID: 8089106
10. Expression, targeting, and assembly of functional Na,K-ATPase polypeptides in baculovirus-infected insect cells.  |  DeTomaso, AW., et al. 1993. J Biol Chem. 268: 1470-8. PMID: 8380413
11. Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase.  |  Mercer, RW., et al. 1993. J Cell Biol. 121: 579-86. PMID: 8387529
12. Structure and function of the Na,K pump: ten years of molecular biology.  |  Pressley, TA. 1996. Miner Electrolyte Metab. 22: 264-71. PMID: 8933497

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-beta 3 Sodium Potassium ATPase/ATP1B3 Antibody (46) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-beta 3 Sodium Potassium ATPase/ATP1B3 Antibody (46) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

beta 3 Sodium Potassium ATPase/ATP1B3 Antibody (46) Specifications

Alternate Product Name: Na+/K+-ATPase β3

Product Clone Name: 46

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 124-243

Epitope Target: Na⁺/K⁺-ATPase β3

Epitope Species: human

Product Reactivity/Detection: Na⁺/K⁺-ATPase β3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for beta 3 Sodium Potassium ATPase/ATP1B3 Antibody (46): N/A