N-SMase Antibody (56-7): sc-100593
- N-SMase Antibody (56-7) is a mouse monoclonal IgG3 κ, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against recombinant N-SMase of human origin
- recommended for detection of N-SMase of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for N-SMase Antibody (56-7). This work is in progress.
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N-SMase Antibody (56-7) is a mouse monoclonal IgG3 antibody that detects neutral sphingomyelinase (N-SMase) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). N-SMase plays a crucial role in cellular signaling by hydrolyzing sphingomyelin to generate ceramide, a bioactive lipid that acts as a second messenger in numerous physiological processes. The generation of ceramide is vital as ceramide regulates key cellular functions such as apoptosis, differentiation, and proliferation, thereby influencing cell fate and homeostasis. Additionally, N-SMase is sensitive to magnesium ions and can be activated by a range of stimuli, including tumor necrosis factor alpha and oxidized low-density lipoproteins, highlighting N-SMase′s importance in mediating responses to extracellular signals. Anti-N-SMase antibody (56-7) is an essential tool for researchers investigating the intricate roles of sphingolipid metabolism in health and disease, providing insights into the mechanisms underlying various cellular responses and potential therapeutic targets.
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N-SMase Antibody (56-7) References:
- Neutral sphingomyelinase inhibition participates to the benefits of N-acetylcysteine treatment in post-myocardial infarction failing heart rats. | Adamy, C., et al. 2007. J Mol Cell Cardiol. 43: 344-53. PMID: 17707397
- Neutral sphingomyelinase and breast cancer research. | Hwang, SY., et al. 2015. J Menopausal Med. 21: 24-7. PMID: 26046034
- The neutral sphingomyelinase 2 in T cell receptor signaling and polarity. | Collenburg, L., et al. 2018. Biol Chem. 399: 1147-1155. PMID: 29337691
- Physiological functions and therapeutic applications of neutral sphingomyelinase and acid sphingomyelinase. | Xiang, H., et al. 2021. Biomed Pharmacother. 139: 111610. PMID: 33957567
- Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound. | Yoo, SW., et al. 2023. Proc Natl Acad Sci U S A. 120: e2219543120. PMID: 37406092
- Neutral sphingomyelinase 2 is required for HIV-1 maturation. | Waheed, AA., et al. 2023. Proc Natl Acad Sci U S A. 120: e2219475120. PMID: 37406093
- Neutral sphingomyelinase blockade enhances hematopoietic stem cell fitness through an integrated stress response. | Hurwitz, SN., et al. 2023. Blood. 142: 1708-1723. PMID: 37699202
- Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo. | Risner, ML., et al. 2023. Cell Commun Signal. 21: 305. PMID: 37904133
- Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation. | Al-Rashed, F., et al. 2024. Cells. 13: PMID: 38474427
- The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells. | Schempp, R., et al. 2024. Int J Mol Sci. 25: PMID: 38542220
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-SMase Antibody (56-7) | sc-100593 | 50 µg/0.5 ml | $333.00 |