N-cadherin Antibody (13A9): sc-59987
- N-cadherin Antibody (13A9) is a mouse monoclonal IgG1 κ, cited in 171 publications, provided at 200 µg/ml
- raised against recombinant N-cadherin cytoplasmic domain fusion protein of human origin
- Anti-N-cadherin Antibody (13A9) is recommended for detection of N-cadherin of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-N-cadherin Antibody (13A9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for N-cadherin Antibody (13A9) for WB and IHC(P) applications. These reagents are now offered in bundles with N-cadherin Antibody (13A9) (see ordering information below).
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N-cadherin Antibody (13A9) is a mouse monoclonal IgG1 kappa light chain antibody that detects N-cadherin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-N-cadherin antibody (13A9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. N-cadherin plays a crucial role in cell adhesion, facilitating binding between cells essential for maintaining tissue integrity and promoting morphogenetic processes. N-cadherin is primarily located at the cell membrane, forming adherens junctions vital for structural stability of tissues. N-cadherin′s presence at these junctions is particularly important during embryonic development and neural tissue maintenance, helping regulate cell signaling pathways and influencing cellular behavior. N-cadherin′s interactions with cytoplasmic proteins, such as β-catenin, underscore its significance in cellular communication and regulation of cell proliferation and differentiation. N-cadherin mediates interactions making this protein a key player in various physiological and pathological processes, including cancer metastasis, where altered expression can lead to increased cell motility and invasion.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
N-cadherin Antibody (13A9) References:
- Genomic organization and chromosomal mapping of the mouse P-cadherin gene. | Hatta, M., et al. 1991. Nucleic Acids Res. 19: 4437-41. PMID: 1886768
- The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. | Takeichi, M. 1988. Development. 102: 639-55. PMID: 3048970
- Desmosomal cadherins: another growing multigene family of adhesion molecules. | Koch, PJ. and Franke, WW. 1994. Curr Opin Cell Biol. 6: 682-7. PMID: 7833048
- Cadherins and catenins: interactions and functions in embryonic development. | Ranscht, B. 1994. Curr Opin Cell Biol. 6: 740-6. PMID: 7833053
- Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. | Tanihara, H., et al. 1994. Cell Adhes Commun. 2: 15-26. PMID: 7982033
- Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells. | Ayalon, O., et al. 1994. J Cell Biol. 126: 247-58. PMID: 8027182
- Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. | Hinck, L., et al. 1994. J Cell Biol. 125: 1327-40. PMID: 8207061
- Morphogenetic roles of classic cadherins. | Takeichi, M. 1995. Curr Opin Cell Biol. 7: 619-27. PMID: 8573335
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-cadherin Antibody (13A9) | sc-59987 | 200 µg/ml | $322.00 | |||
N-cadherin Antibody (13A9): m-IgG Fc BP-HRP Bundle | sc-526950 | 200 µg Ab; 10 µg BP | $361.00 | |||
N-cadherin Antibody (13A9): m-IgG1 BP-HRP Bundle | sc-532323 | 200 µg Ab; 20 µg BP | $361.00 | |||
N-cadherin Antibody (13A9) AC | sc-59987 AC | 500 µg/ml, 25% agarose | $424.00 | |||
N-cadherin Antibody (13A9) HRP | sc-59987 HRP | 200 µg/ml | $322.00 | |||
N-cadherin Antibody (13A9) FITC | sc-59987 FITC | 200 µg/ml | $336.00 | |||
N-cadherin Antibody (13A9) PE | sc-59987 PE | 200 µg/ml | $349.00 | |||
N-cadherin Antibody (13A9) Alexa Fluor® 488 | sc-59987 AF488 | 200 µg/ml | $364.00 | |||
N-cadherin Antibody (13A9) Alexa Fluor® 546 | sc-59987 AF546 | 200 µg/ml | $364.00 | |||
N-cadherin Antibody (13A9) Alexa Fluor® 594 | sc-59987 AF594 | 200 µg/ml | $364.00 | |||
N-cadherin Antibody (13A9) Alexa Fluor® 647 | sc-59987 AF647 | 200 µg/ml | $364.00 | |||
N-cadherin Antibody (13A9) Alexa Fluor® 680 | sc-59987 AF680 | 200 µg/ml | $364.00 | |||
N-cadherin Antibody (13A9) Alexa Fluor® 790 | sc-59987 AF790 | 200 µg/ml | $364.00 |