MZT2A/B Antibody (B-10): sc-514516
- MZT2A/B Antibody (B-10) is a mouse monoclonal IgG2b κ MZT2A/B antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 126-145 near the C-terminus of FAM128B of human origin
- MZT2A/B Antibody (B-10) is recommended for detection of MZT2A and MZT2B of human origin by WB, IP, IF and ELISA
- Anti-MZT2A/B Antibody (B-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MZT2A/B Antibody (B-10) for WB applications. These reagents are now offered in bundles with MZT2A/B Antibody (B-10) (see ordering information below).
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SEE ALSO...
MZT2A/B Antibody (B-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects MZT2A/B of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MZT2A/B (B-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MZT2A and MZT2B proteins, also known as FAM128A and FAM128B, are crucial components of the MOZART2 family, consisting of 158 amino acids each. MZT2A and MZT2B play a significant role in organizing the mitotic spindle during cell division, which is essential for accurate chromosome segregation and maintaining genomic stability. Disruptions in this process can lead to aneuploidy and various cancers, highlighting MZT2A/B′s importance in cellular function and disease. The genes encoding MZT2A and MZT2B are located on chromosome 2q21, a region associated with several genetic disorders, underscoring MZT2A/B′s relevance in both normal physiology and pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MZT2A/B Antibody (B-10) References:
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
- Evidence for an ancestral alphoid domain on the long arm of human chromosome 2. | Avarello, R., et al. 1992. Hum Genet. 89: 247-9. PMID: 1587535
- ABCA12 is the major harlequin ichthyosis gene. | Thomas, AC., et al. 2006. J Invest Dermatol. 126: 2408-13. PMID: 16902423
- Regulation of intestinal cholesterol absorption. | Wang, DQ. 2007. Annu Rev Physiol. 69: 221-48. PMID: 17002594
- A two-carbon switch to sterol-induced autophagic death. | Tabas, I. 2007. Autophagy. 3: 38-41. PMID: 17172803
- Spectrum of ALMS1 variants and evaluation of genotype-phenotype correlations in Alström syndrome. | Marshall, JD., et al. 2007. Hum Mutat. 28: 1114-23. PMID: 17594715
- Compound heterozygous ABCA12 mutations including a novel nonsense mutation underlie harlequin ichthyosis. | Akiyama, M., et al. 2007. Dermatology. 215: 155-9. PMID: 17684380
- Alström syndrome. | Marshall, JD., et al. 2007. Eur J Hum Genet. 15: 1193-202. PMID: 17940554
- Origin of human chromosome 2: an ancestral telomere-telomere fusion. | IJdo, JW., et al. 1991. Proc Natl Acad Sci U S A. 88: 9051-5. PMID: 1924367
- MZT2A promotes NSCLC viability and invasion by increasing Akt phosphorylation via the MOZART2 domain. | Wang, H., et al. 2021. Cancer Sci. 112: 2210-2222. PMID: 33754417
- AZD9291-resistant non-small cell lung cancer cell-derived exosomal lnc-MZT2A-5:1 induces the activation of fibroblasts. | Song, L., et al. 2021. Ann Transl Med. 9: 1593. PMID: 34790799
- MZT2A serves as a prognostic biomarker and promotes the progression of kidney renal clear cell carcinoma. | Cao, L., et al. 2024. Heliyon. 10: e35695. PMID: 39170571
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MZT2A/B Antibody (B-10) | sc-514516 | 200 µg/ml | $322.00 | |||
MZT2A/B Antibody (B-10): m-IgGκ BP-HRP Bundle | sc-524751 | 200 µg Ab, 40 µg BP | $361.00 | |||
MZT2A/B Antibody (B-10): m-IgG2b BP-HRP Bundle | sc-549176 | 200 µg Ab; 10 µg BP | $361.00 | |||
MZT2A/B Antibody (B-10) AC | sc-514516 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MZT2A/B Antibody (B-10) HRP | sc-514516 HRP | 200 µg/ml | $322.00 | |||
MZT2A/B Antibody (B-10) FITC | sc-514516 FITC | 200 µg/ml | $336.00 | |||
MZT2A/B Antibody (B-10) PE | sc-514516 PE | 200 µg/ml | $349.00 | |||
MZT2A/B Antibody (B-10) Alexa Fluor® 488 | sc-514516 AF488 | 200 µg/ml | $364.00 | |||
MZT2A/B Antibody (B-10) Alexa Fluor® 546 | sc-514516 AF546 | 200 µg/ml | $364.00 | |||
MZT2A/B Antibody (B-10) Alexa Fluor® 594 | sc-514516 AF594 | 200 µg/ml | $364.00 | |||
MZT2A/B Antibody (B-10) Alexa Fluor® 647 | sc-514516 AF647 | 200 µg/ml | $364.00 | |||
MZT2A/B Antibody (B-10) Alexa Fluor® 680 | sc-514516 AF680 | 200 µg/ml | $364.00 | |||
MZT2A/B Antibody (B-10) Alexa Fluor® 790 | sc-514516 AF790 | 200 µg/ml | $364.00 | |||
MZT2A/B (B-10) Neutralizing Peptide | sc-514516 P | 100 µg/0.5 ml | $69.00 |