Myozenin 2 Antibody (B-4): sc-373876

Myozenin 2 Antibody (B-4) is a mouse monoclonal IgG1 antibody that detects Myozenin 2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Myozenin 2, also known as calsarcin-1, plays a crucial role in muscle physiology by acting as a key regulator of calcineurin signaling, which is essential for proper expression of slow fiber genes in skeletal muscle and hypertrophic response in cardiac muscle. Myozenin 2 is strategically located at the Z-line of the sarcomere, where Myozenin 2 binds calcineurin to α-actinin, thereby linking calcium signaling to muscle contraction and adaptation. Myozenin 2′s location facilitates the integration of calcium-dependent signaling pathways with structural components of muscle, ensuring muscle cells can respond appropriately to physiological demands. Myozenin 2 is specifically expressed in adult cardiac and slow-twitch skeletal muscle, highlighting specialized function in these tissues, while Myozenin 1 is predominantly found in fast skeletal muscle. With unique properties and critical role in muscle function, anti-Myozenin 2 antibody (B-4) serves as an invaluable tool for researchers studying muscle biology and related disorders.

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Myozenin 2 Antibody (B-4) References:

1. The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.  |  Gontier, Y., et al. 2005. J Cell Sci. 118: 3739-49. PMID: 16076904
2. Atrial natriuretic peptide and osteopontin are useful markers of cardiac disorders in mice.  |  Schoensiegel, F., et al. 2007. Comp Med. 57: 546-53. PMID: 18246866
3. Sequence analysis of myozenin 2 in 438 European patients with familial hypertrophic cardiomyopathy.  |  Posch, MG., et al. 2008. Med Sci Monit. 14: CR372-4. PMID: 18591919
4. A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies.  |  von Nandelstadh, P., et al. 2009. Mol Cell Biol. 29: 822-34. PMID: 19047374
5. Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity.  |  Ruggiero, A., et al. 2013. Cardiovasc Res. 97: 44-54. PMID: 22987565
6. Myocyte enhancer factor 2A promotes proliferation and its inhibition attenuates myogenic differentiation via myozenin 2 in bovine skeletal muscle myoblast.  |  Wang, YN., et al. 2018. PLoS One. 13: e0196255. PMID: 29698438
7. Quantitative proteomics analysis to identify biomarkers of chronic myofascial pain and therapeutic targets of dry needling in a rat model of myofascial trigger points.  |  Li, LH., et al. 2019. J Pain Res. 12: 283-298. PMID: 30662282
8. Potential links between COVID-19 and periodontitis: a bioinformatic analysis based on GEO datasets.  |  Zhang, C., et al. 2022. BMC Oral Health. 22: 520. PMID: 36414950
9. Research Note: Transcriptome analysis reveals differentially expressed genes regulated muscle development in Pekin ducks during dietary threonine deficiency.  |  Jia, W., et al. 2023. Poult Sci. 102: 103168. PMID: 37918132
10. Explorations on Key Module and Hub Genes Affecting IMP Content of Chicken Pectoralis Major Muscle Based on WGCNA.  |  He, X., et al. 2024. Animals (Basel). 14: PMID: 38338044

The preferred Myozenin 2 antibody is Myozenin 2 Antibody (E-11): sc-377359.